Journal article
Hepatocellular carcinoma with a direct right atrial extension in an HCV patient previously treated with direct-acting antiviral therapy: a case report
The Egyptian heart journal, Vol.71(1), pp.5-5
09/13/2019
DOI: 10.1186/s43044-019-0012-4
PMCID: PMC6821414
PMID: 31659529
Abstract
Background
Hepatocellular carcinoma (HCC) is considered the third-leading cause of cancer-related mortality worldwide. Most cases of HCC are usually associated with liver cirrhosis due to various causes such as alcohol or more commonly viral hepatitis. Usually, patients remain asymptomatic for a long time, and symptoms are usually related to the cirrhosis itself or secondary to tumor extension. Intra-cardiac involvement with HCC rarely develops with a very poor prognosis. The occurrence and recurrence of HCC in cirrhotic patients treated with direct-acting antiviral (DAA) therapy (sofosbuvir) have been discussed in a few trials so far with no valid answer.
Case presentation
We are reporting a case of recurrent HCC with an accidentally discovered direct right atrial extension with tumor thrombus through the inferior vena cava (IVC) in a cirrhotic patient previously treated with DAA. Unfortunately, due to his critical general condition, he died within days.
Conclusion
Cardiac involvement in HCC rarely occurs and usually develops in advanced stages of HCC with very poor reported prognosis. Data regarding the relation between DAA and HCC development is controversial.
Details
- Title: Subtitle
- Hepatocellular carcinoma with a direct right atrial extension in an HCV patient previously treated with direct-acting antiviral therapy: a case report
- Creators
- Mahmoud Abdelnabi - Alexandria UniversityAbdallah Almaghraby - Alexandria UniversityYehia Saleh - Alexandria UniversitySherif Abd Elsamad - Cardiology and Angiology Unit, Department of Clinical and Experimental Internal Medicine, Medical Research Institute, University of Alexandria
- Resource Type
- Journal article
- Publication Details
- The Egyptian heart journal, Vol.71(1), pp.5-5
- DOI
- 10.1186/s43044-019-0012-4
- PMID
- 31659529
- PMCID
- PMC6821414
- NLM abbreviation
- Egypt Heart J
- ISSN
- 1110-2608
- eISSN
- 2090-911X
- Publisher
- Springer Berlin Heidelberg
- Language
- English
- Date published
- 09/13/2019
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984756264902771
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