Hepatocyte Cytokeratin 7 Expression in Chronic Allograft Rejection

Andrew M BELLIZZI; Robin D LEGALLO; James C BOYD; Julia C IEZZONI

doi:10.1309/AJCPNRXCAP92KNOJ

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Hepatocyte Cytokeratin 7 Expression in Chronic Allograft Rejection

Journal article

Open access

Peer reviewed

Hepatocyte Cytokeratin 7 Expression in Chronic Allograft Rejection

Andrew M BELLIZZI, Robin D LEGALLO, James C BOYD and Julia C IEZZONI

American journal of clinical pathology, Vol.135(2), pp.238-244

2011

DOI: 10.1309/AJCPNRXCAP92KNOJ

PMID: 21228364

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Abstract

We examined hepatocyte cytokeratin 7 (CK7) expression in chronic allograft rejection (CR), a ductopenic condition in which this has not been systematically evaluated, in 20 patients with the clinicopathologic diagnosis of CR and age-, sex-, and native-disease-matched control subjects. We also studied baseline biopsy specimens from both groups. Three pathologists independently reviewed H&E- and CK7-stained sections, counting interlobular bile ducts (BDs) and portal tracts (PTs), noting the morphologic pattern of injury and scoring hepatocyte CK7 expression (0, none; 1+, rare; 2+, multifocal, predominantly periportal; 3+, extension into the lobule; 4+, diffuse). Mean BD/PT ratios and CK7 scores were calculated. The mean BD/PT ratio (0.58) and CK7 score (1.01) for the "CR, diagnostic" group were significantly different from all other group means (P < .05); no other comparisons were significant (P > .05). A CK7 score of 1 or more was observed in 9 (56%) of 16 CR specimens and in 3 (7%) of 41 remaining specimens. Hepatocyte CK7 expression is frequently noted in CR, and it would appear to reflect ductopenia. CK7 staining may be a useful diagnostic adjunct in evaluation of transplant liver biopsy specimens.

Gastroenterology. Liver. Pancreas. Abdomen

Investigative techniques, diagnostic techniques (general aspects)

Liver. Biliary tract. Portal circulation. Exocrine pancreas

Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques

Biological and medical sciences

Medical sciences

Other diseases. Semiology

Details

Title: Subtitle: Hepatocyte Cytokeratin 7 Expression in Chronic Allograft Rejection
Creators: Andrew M BELLIZZI - Departments of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
Robin D LEGALLO - University of Virginia Health System, Charlottesville, United States
James C BOYD - University of Virginia Health System, Charlottesville, United States
Julia C IEZZONI - University of Virginia Health System, Charlottesville, United States
Resource Type: Journal article
Publication Details: American journal of clinical pathology, Vol.135(2), pp.238-244
Publisher: American Society of Clinical Pathologists; Chicago, IL
DOI: 10.1309/AJCPNRXCAP92KNOJ
PMID: 21228364
ISSN: 0002-9173
eISSN: 1943-7722
Language: English
Date published: 2011
Academic Unit: Pathology
Record Identifier: 9984047990602771

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