Journal article
Herbicide use in farming and other jobs in relation to non-Hodgkin’s lymphoma (NHL) risk
Occupational and environmental medicine (London, England), Vol.79(12), pp.795-806
10/07/2022
DOI: 10.1136/oemed-2022-108371
PMCID: PMC9669193
PMID: 36207110
Abstract
ObjectivesGiven mixed evidence for carcinogenicity of current-use herbicides, we studied the relationship between occupational herbicide use and risk of non-Hodgkin’s lymphoma (NHL) in a large, pooled study.MethodsWe pooled data from 10 case-control studies participating in the International Lymphoma Epidemiology Consortium, including 9229 cases and 9626 controls from North America, the European Union and Australia. Herbicide use was coded from self-report or by expert assessment in the individual studies, for herbicide groups (eg, phenoxy herbicides) and active ingredients (eg, 2,4-dichlorophenoxyacetic acid (2,4-D), glyphosate). The association between each herbicide and NHL risk was estimated using logistic regression to produce ORs and 95% CIs, with adjustment for sociodemographic factors, farming and other pesticides.ResultsWe found no substantial association of all NHL risk with ever-use of any herbicide (OR=1.10, 95% CI: 0.94 to 1.29), nor with herbicide groups or active ingredients. Elevations in risk were observed for NHL subtypes with longer duration of phenoxy herbicide use, such as for any phenoxy herbicide with multiple myeloma (>25.5 years, OR=1.78, 95% CI: 0.74 to 4.27), 2,4-D with diffuse large B-cell lymphoma (>25.5 years, OR=1.47, 95% CI: 0.67 to 3.21) and other (non-2,4-D) phenoxy herbicides with T-cell lymphoma (>6 years, lagged 10 years, OR=3.24, 95% CI: 1.03 to 10.2). An association between glyphosate and follicular lymphoma (lagged 10 years: OR=1.48, 95% CI: 0.98 to 2.25) was fairly consistent across analyses.ConclusionsMost of the herbicides examined were not associated with NHL risk. However, associations of phenoxy herbicides and glyphosate with particular NHL subtypes underscore the importance of estimating subtype-specific risks.
Details
- Title: Subtitle
- Herbicide use in farming and other jobs in relation to non-Hodgkin’s lymphoma (NHL) risk
- Creators
- Anneclaire J De Roos - Drexel UniversityLin Fritschi - Curtin UniversityMary H Ward - National Institutes of HealthAlain Monnereau - Sorbonne Paris CitéJonathan Hofmann - National Institutes of HealthLeslie Bernstein - City Of Hope National Medical CenterParveen Bhatti - Cancer Control Research, BC Cancer, Vancouver, British Columbia, CanadaYolanda Benavente Moreno - Instituto de Salud Carlos IIIGeza Benke - Monash UniversityDelphine Casabonne - Instituto de Salud Carlos IIIJacqueline Clavel - Sorbonne Paris CitéPierluigi Cocco - University of CagliariTran Huynh - Drexel UniversityAndrea 't Mannetje - Massey UniversityLucia Miligi - Florence (Netherlands)Sara Piro - Florence (Netherlands)Nathaniel Rothman - National Institutes of HealthLeah H Schinasi - Drexel UniversityClaire M Vajdic - UNSW SydneySophia S Wang - City Of Hope National Medical CenterYawei Zhang - National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaSusan L Slager - Mayo ClinicJames R Cerhan - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- Occupational and environmental medicine (London, England), Vol.79(12), pp.795-806
- DOI
- 10.1136/oemed-2022-108371
- PMID
- 36207110
- PMCID
- PMC9669193
- NLM abbreviation
- Occup Environ Med
- ISSN
- 1351-0711
- eISSN
- 1470-7926
- Publisher
- BMJ Publishing Group Ltd
- Grant note
- R03CA199515 / National Cancer Institute of the National Institutes of Health
- Language
- English
- Date published
- 10/07/2022
- Academic Unit
- Epidemiology
- Record Identifier
- 9984368097202771
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