Journal article
Hereditary Breast Cancer, Genetics, and Fertility Preservation
Current breast cancer reports, Vol.15(4), pp.329-336
2023
DOI: 10.1007/s12609-023-00515-0
Abstract
Purpose of Review
Fertility preservation is an important consideration in patients with hereditary breast cancer. Breast cancer mutation carriers may present with their cancers at younger ages and require more gonadotoxic treatments. The intent of this review is to discuss the data and research behind the particular fertility challenges mutation carriers may encounter.
Recent Findings
Limited data exist for the impact of hereditary breast cancer genes on fertility in breast cancer patients. Data is conflicting on baseline fertility of
BRCA1/2
carriers, but breast cancer patients with these mutations become pregnant more often than noncarrier patients. Artificial reproductive technologies (ART) appear to be safe in this patient population, and these patients may benefit from preimplantation genetic testing.
Summary
Discussion of future fertility is important at time of diagnosis of a cancer mutation and breast cancer. Additional research is needed on mutation carriers to determine how their pathogenic variants affect fertility and risks of fertility preservation options.
Details
- Title: Subtitle
- Hereditary Breast Cancer, Genetics, and Fertility Preservation
- Creators
- Kathryn J. Huber-Keener - Holden Comprehensive Cancer Center, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Current breast cancer reports, Vol.15(4), pp.329-336
- Publisher
- Springer US
- DOI
- 10.1007/s12609-023-00515-0
- ISSN
- 1943-4588
- eISSN
- 1943-4596
- Language
- English
- Date published
- 2023
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984536845202771
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