Journal article
Heritability of Multivariate Gray Matter Measures in Schizophrenia
Twin research and human genetics, Vol.15(3), pp.324-335
06/2012
DOI: 10.1017/thg.2012.1
PMCID: PMC3694574
PMID: 22856368
Abstract
Structural brain measures are employed as endophenotypes in the search for schizophrenia susceptibility genes. We analyzed two independent structural imaging datasets with voxel-based morphometry and with source-based morphometry, a multivariate, independent components analysis, to determine the stability and heritability of regional gray matter concentration abnormalities in schizophrenia. The samples comprised 209 and 102 patients with schizophrenia and 208 and 96 healthy volunteers, respectively. The second sample additionally included non-ill siblings of participants with and without schizophrenia. A standard voxel-based analysis showed reproducible regional gray matter deficits in the affected participants compared with unrelated, unaffected controls in both datasets: patients showed significant gray matter concentration deficits in cortical frontal, temporal, and insular lobes. Source-based morphometry (SBM) was applied to the gray matter images of the entire sample to determine the effects of diagnosis on networks of covarying structures. The SBM analysis extracted 24 significant sets of covarying regions (components). Four of these components showed significantly lower gray matter concentrations in patients (
Details
- Title: Subtitle
- Heritability of Multivariate Gray Matter Measures in Schizophrenia
- Creators
- Jessica A Turner - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USAVince D Calhoun - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USAAndrew Michael - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USATheo G. M van Erp - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USAStefan Ehrlich - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USAJudith M Segall - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USARandy L Gollub - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USAJohn Csernansky - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USASteven G Potkin - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USABeng-Choon Ho - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USAJuan Bustillo - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USAS. Charles Schulz - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USAFunctional Imaging Biomedical Informatics Research NetworkLei Wang - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA
- Resource Type
- Journal article
- Publication Details
- Twin research and human genetics, Vol.15(3), pp.324-335
- DOI
- 10.1017/thg.2012.1
- PMID
- 22856368
- PMCID
- PMC3694574
- ISSN
- 1832-4274
- eISSN
- 1839-2628
- Grant note
- R01 MH084803 || MH / National Institute of Mental Health : NIMH U24 RR025736 || RR / National Center for Research Resources : NCRR R01 MH056584 || MH / National Institute of Mental Health : NIMH U24 RR021992 || RR / National Center for Research Resources : NCRR
- Language
- English
- Date published
- 06/2012
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003401602771
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