Herpes Simplex Virus 1 Induces Phosphorylation and Reorganization of Lamin A/C through the γ134.5 Protein That Facilitates Nuclear Egress

Songfang Wu; Shuang Pan; Liming Zhang; Joel Baines; Richard Roller; Joshua Ames; Mengmeng Yang; Jiyan Wang; Da Chen; Yaohui Liu; Cuizhu Zhang; Youjia Cao; Bin He

doi:10.1128/JVI.01392-16

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Herpes Simplex Virus 1 Induces Phosphorylation and Reorganization of Lamin A/C through the γ134.5 Protein That Facilitates Nuclear Egress

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Herpes Simplex Virus 1 Induces Phosphorylation and Reorganization of Lamin A/C through the γ134.5 Protein That Facilitates Nuclear Egress

Songfang Wu, Shuang Pan, Liming Zhang, Joel Baines, Richard Roller, Joshua Ames, Mengmeng Yang, Jiyan Wang, Da Chen, Yaohui Liu, …

Journal of virology, Vol.90(22), pp.10414-10422

11/15/2016

DOI: 10.1128/JVI.01392-16

PMCID: PMC5105674

PMID: 27630226

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Abstract

Herpes simplex virus 1 (HSV-1) remodels nuclear membranes during virus egress. Although the UL31 and UL34 proteins control nucleocapsid transit in infected cells, the molecular interactions required for their function are unclear. Here we report that the γ

Phosphorylation - physiology

Herpesvirus 1, Human - metabolism

Nuclear Lamina - virology

Humans

Cytoplasm - virology

Cercopithecus aethiops

Cytoplasm - metabolism

Nuclear Envelope - virology

Nuclear Proteins - metabolism

Virus Assembly - physiology

Lamin Type A - metabolism

Viral Proteins - metabolism

Nuclear Envelope - metabolism

Animals

Cell Nucleus - metabolism

Nuclear Lamina - metabolism

Nucleocapsid - metabolism

Protein Kinase C - metabolism

Cell Nucleus - virology

Virus Release - physiology

Cell Line, Tumor

HeLa Cells

Capsid - metabolism

Vero Cells

Details

Title: Subtitle: Herpes Simplex Virus 1 Induces Phosphorylation and Reorganization of Lamin A/C through the γ134.5 Protein That Facilitates Nuclear Egress
Creators: Songfang Wu - Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin, People's Republic of China
Shuang Pan - Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin, People's Republic of China
Liming Zhang - Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin, People's Republic of China
Joel Baines - Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, Louisiana, USA
Richard Roller - Department of Microbiology, University of Iowa, Iowa City, Iowa, USA
Joshua Ames - Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, Illinois, USA
Mengmeng Yang - Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin, People's Republic of China
Jiyan Wang - Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin, People's Republic of China
Da Chen - Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin, People's Republic of China
Yaohui Liu - Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin, People's Republic of China
Cuizhu Zhang - Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin, People's Republic of China
Youjia Cao - Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin, People's Republic of China tshuo@uic.edu caoyj@nankai.edu.cn
Bin He - University of Illinois at Chicago
Resource Type: Journal article
Publication Details: Journal of virology, Vol.90(22), pp.10414-10422
Publisher: United States
DOI: 10.1128/JVI.01392-16
PMID: 27630226
PMCID: PMC5105674
ISSN: 0022-538X
eISSN: 1098-5514
Grant note: R21 AI112755 / NIAID NIH HHS
Language: English
Date published: 11/15/2016
Academic Unit: Microbiology and Immunology
Record Identifier: 9984001149602771

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