Herpes simplex encephalitis in the temporal cortex and limbic system after trigeminal nerve inoculation

Edward M Barnett; Gary Jacobsen; Gregory Evans; Martin Cassell; Stanley Perlman

doi:10.1093/infdis/169.4.782

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Herpes simplex encephalitis in the temporal cortex and limbic system after trigeminal nerve inoculation

Journal article

Peer reviewed

Herpes simplex encephalitis in the temporal cortex and limbic system after trigeminal nerve inoculation

Edward M Barnett, Gary Jacobsen, Gregory Evans, Martin Cassell and Stanley Perlman

The Journal of infectious diseases, Vol.169(4), pp.782-786

04/1994

DOI: 10.1093/infdis/169.4.782

PMID: 8133092

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Abstract

Herpes simplex virus type 1 causes an encephalitis in humans that is primarily restricted to the temporal lobe and limbic system. The distribution of lesions suggests that virus enters the brain from a single site and then spreads transneuronally to infect connected structures. Two obvious sites of potential viral entry are the olfactory and trigeminal nerves. Trigeminal nerve entry is more likely because it innervates the oral cavity, a common site of initial infection, and the trigeminal ganglion is the most common site of viral latency. In previous reports, however, experimental trigeminal nerve infection has never led to the pattern of disease observed in humans. By directly inoculating virus into the murine tooth pulp, the mandibular division of the trigeminal nerve was selectively infected. This division, which innervates the oral cavity, is the one most commonly infected in humans. Intrapulp inoculation led to an encephalitis primarily affecting the temporal cortex and limbic system. Thus, spread via the trigeminal nerve provides an explanation for the distribution of herpes simplex virus observed in the human encephalitis.

Herpesvirus 1, Human - physiology

Trigeminal Nerve - microbiology

Animals

In Situ Hybridization

Specific Pathogen-Free Organisms

Herpes Simplex - microbiology

Limbic System - microbiology

Mice

Mice, Inbred BALB C

Temporal Lobe - microbiology

Encephalitis - microbiology

Details

Title: Subtitle: Herpes simplex encephalitis in the temporal cortex and limbic system after trigeminal nerve inoculation
Creators: Edward M Barnett - Neuroscience Program, College of Dentistry, University of Iowa, Iowa City
Gary Jacobsen
Gregory Evans
Martin Cassell
Stanley Perlman
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.169(4), pp.782-786
DOI: 10.1093/infdis/169.4.782
PMID: 8133092
NLM abbreviation: J Infect Dis
ISSN: 0022-1899
eISSN: 1537-6613
Publisher: United States
Grant note: DC-01311 / NIDCD NIH HHS NS-24401 / NINDS NIH HHS
Language: English
Date published: 04/1994
Academic Unit: Preventive and Community Dentistry; Microbiology and Immunology; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9983777468402771

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