Herpesvirus and neurological manifestations in patients with severe coronavirus disease

Vanessa Cristine de Souza Carneiro; Soniza Vieira Alves-Leon; Dmitry José de Santana Sarmento; Wagner Luis da Costa Nunes Pimentel Coelho; Otacilio da Cruz Moreira; Andreza Lemos Salvio; Carlos Henrique Ferreira Ramos; Carlos Henrique Ferreira Ramos Filho; Carla Augusta Barreto Marques; João Paulo da Costa Gonçalves; Luciane Almeida Amado Leon; Vanessa Salete de Paula

doi:10.1186/s12985-022-01828-9

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Herpesvirus and neurological manifestations in patients with severe coronavirus disease

Journal article

Open access

Peer reviewed

Herpesvirus and neurological manifestations in patients with severe coronavirus disease

Vanessa Cristine de Souza Carneiro, Soniza Vieira Alves-Leon, Dmitry José de Santana Sarmento, Wagner Luis da Costa Nunes Pimentel Coelho, Otacilio da Cruz Moreira, Andreza Lemos Salvio, Carlos Henrique Ferreira Ramos, Carlos Henrique Ferreira Ramos Filho, Carla Augusta Barreto Marques, João Paulo da Costa Gonçalves, …

Virology journal, Vol.19(1), pp.101-101

06/08/2022

DOI: 10.1186/s12985-022-01828-9

PMID: 35676707

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Abstract

Certain clinical manifestations of coronavirus disease (COVID-19) mimic those associated with human herpesvirus (HHV) infection. In this study, we estimated the prevalence of herpesvirus in patients with COVID-19 and determined if coinfection is associated with poorer outcomes and neurological symptoms. We analyzed samples of 53 patients diagnosed with COVID-19. The samples were evaluated for the presence of alphaherpesviruses, betaherpesviruses, and gammaherpesviruses, and the viral loads were quantified using quantitative polymerase chain reaction (qPCR) method. Among the patients, in 79.2% had detection at least one type of herpesvirus. HHV-6 (47.2%), cytomegalovirus (43.3%), and HHV-7 (39.6%) showed the highest detection rates. Patients with a high severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) load were more likely to show herpes simplex virus 1 detection (p = 0.037). Among patients coinfected with SARS-CoV-2 and HHVs, 26.4% showed central nervous system-associated neurological symptoms and herpetic manifestations. A statistically significant association was observed between neurological changes and HHV-6 detection (p = 0.034). The findings showed a high prevalence of herpesvirus in patients with COVID-19. Furthermore, even though SARS-CoV-2 and HHV coinfection was not associated with poorer outcomes, the findings demonstrated the association between neurological symptoms and HHV-6 detection.

COVID-19 - complications

Cytomegalovirus

Herpesviridae

Herpesviridae Infections - complications

Herpesviridae Infections - epidemiology

Herpesvirus 6, Human

Herpesvirus 7, Human

Humans

SARS-CoV-2

Details

Title: Subtitle: Herpesvirus and neurological manifestations in patients with severe coronavirus disease
Creators: Vanessa Cristine de Souza Carneiro - Laboratory of Technological Development in Virology, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil
Soniza Vieira Alves-Leon - Universidade Federal do Rio de Janeiro
Dmitry José de Santana Sarmento - Department of Oral Diagnosis, School of Dentistry, State University of Paraíba, Araruna, PB, Brazil
Wagner Luis da Costa Nunes Pimentel Coelho - Laboratory of Technological Development in Virology, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil
Otacilio da Cruz Moreira - Real Time PCR Platform RPT09A, Laboratory of Molecular Biology and Endemic Diseases, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil
Andreza Lemos Salvio - Universidade Federal do Estado do Rio de Janeiro
Carlos Henrique Ferreira Ramos - Universidade Federal do Estado do Rio de Janeiro
Carlos Henrique Ferreira Ramos Filho - Laboratory of Translacional Neurosciences, Biomedical Institute, Federal University of the State of Rio de Janeiro/UNIRIO, Rio de Janeiro, Brazil
Carla Augusta Barreto Marques - Universidade Federal do Estado do Rio de Janeiro
João Paulo da Costa Gonçalves - Universidade Federal do Rio de Janeiro
Luciane Almeida Amado Leon - Fundação Oswaldo Cruz
Vanessa Salete de Paula - Fundação Oswaldo Cruz
Resource Type: Journal article
Publication Details: Virology journal, Vol.19(1), pp.101-101
DOI: 10.1186/s12985-022-01828-9
PMID: 35676707
NLM abbreviation: Virol J
ISSN: 1743-422X
eISSN: 1743-422X
Language: English
Date published: 06/08/2022
Academic Unit: Neurology
Record Identifier: 9985180936902771

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