Journal article
Heterochromatin, position effects, and the genetic dissection of chromatin
Progress in nucleic acid research and molecular biology, Vol.74, pp.275-299
2003
DOI: 10.1016/S0079-6603(03)01016-X
PMID: 14510079
Abstract
The partitioning of the eukaryotic chromosome regions into heterochromatin and euchromatin reflects fundamental differences in the packaging of DNA. The observation that chromosome rearrangments juxtaposing euchromatic sequences with heterochromatic regions usually result in silencing of nearby euchromatic genes (termed “position effect silencing”) led to genetic screens for position effect modifiers. These screens uncovered key proteins involved in chromatin assembly, including structural components of heterochromatin and euchromatin, and enzymes that covalently modify histones. In addition, recent data implicates RNA in the targeting of chromosome regions for heterochromatin assembly. Here, we review the genetic, cytological, and biochemical properties of heterochromatin and summarize recent data suggesting mechanisms for heterochromatin assembly.
Details
- Title: Subtitle
- Heterochromatin, position effects, and the genetic dissection of chromatin
- Creators
- Joel C Eissenberg - Department of Biochemistry and Molecular Biology, St. Louis School of Medicine, St. Louis, Missouri 63104, USALori L Wallrath
- Resource Type
- Journal article
- Publication Details
- Progress in nucleic acid research and molecular biology, Vol.74, pp.275-299
- Publisher
- United States
- DOI
- 10.1016/S0079-6603(03)01016-X
- PMID
- 14510079
- ISSN
- 0079-6603
- Grant note
- R01GM061513 / NIGMS NIH HHS
- Language
- English
- Date published
- 2003
- Academic Unit
- Biochemistry and Molecular Biology; University College Courses
- Record Identifier
- 9984024514902771
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