Heterogeneity and matching of ventilation and perfusion within anatomical lung units in rats

Robb W Glenny; Christian Bauer; Johannes Hofmanninger; Wayne J Lamm; Melissa A Krueger; Reinhard R Beichel

doi:10.1016/j.resp.2013.07.027

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Heterogeneity and matching of ventilation and perfusion within anatomical lung units in rats

Journal article

Peer reviewed

Heterogeneity and matching of ventilation and perfusion within anatomical lung units in rats

Robb W Glenny, Christian Bauer, Johannes Hofmanninger, Wayne J Lamm, Melissa A Krueger and Reinhard R Beichel

Respiratory physiology & neurobiology, Vol.189(3), pp.594-606

12/01/2013

DOI: 10.1016/j.resp.2013.07.027

PMCID: PMC3834008

PMID: 23942308

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Abstract

Prior studies exploring the spatial distributions of ventilation and perfusion have partitioned the lung into discrete regions not constrained by anatomical boundaries and may blur regional differences in perfusion and ventilation. To characterize the anatomical heterogeneity of regional ventilation and perfusion, we administered fluorescent microspheres to mark regional ventilation and perfusion in five Sprague–Dawley rats and then using highly automated computer algorithms, partitioned the lungs into regions defined by anatomical structures identified in the images. The anatomical regions ranged in size from the near-acinar to the lobar level. Ventilation and perfusion were well correlated at the smallest anatomical level. Perfusion and ventilation heterogeneity were relatively less in rats compared to data previously published in larger animals. The more uniform distributions may be due to a smaller gravitational gradient and/or the fewer number of generations in the distribution trees before reaching the level of gas exchange, making regional matching of ventilation and perfusion less extensive in small animals.

Ventilation–perfusion matching

Gas exchange

Imaging

Functional unit of gas exchange

Regional pulmonary blood flow

Regional ventilation

Details

Title: Subtitle: Heterogeneity and matching of ventilation and perfusion within anatomical lung units in rats
Creators: Robb W Glenny - University of Washington, Seattle, USA
Christian Bauer - University of Iowa, Iowa City, USA
Johannes Hofmanninger - Vienna University of Technology, Vienna, Austria
Wayne J Lamm - University of Washington, Seattle, USA
Melissa A Krueger - University of Washington, Seattle, USA
Reinhard R Beichel - University of Iowa, Iowa City, USA
Resource Type: Journal article
Publication Details: Respiratory physiology & neurobiology, Vol.189(3), pp.594-606
DOI: 10.1016/j.resp.2013.07.027
PMID: 23942308
PMCID: PMC3834008
NLM abbreviation: Respir Physiol Neurobiol
ISSN: 1569-9048
eISSN: 1878-1519
Publisher: Elsevier B.V
Grant note: name: NIH, award: R21HL110000, R01HL073598
Language: English
Date published: 12/01/2013
Academic Unit: Electrical and Computer Engineering
Record Identifier: 9984083244802771

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