Heterogeneity of B Cell Functions in Stroke-Related Risk, Prevention, Injury, and Repair

Uma Maheswari Selvaraj; Katherine Poinsatte; Vanessa Torres; Sterling B Ortega; Ann M Stowe

doi:10.1007/s13311-016-0460-4

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Heterogeneity of B Cell Functions in Stroke-Related Risk, Prevention, Injury, and Repair

Journal article

Open access

Peer reviewed

Heterogeneity of B Cell Functions in Stroke-Related Risk, Prevention, Injury, and Repair

Uma Maheswari Selvaraj, Katherine Poinsatte, Vanessa Torres, Sterling B Ortega and Ann M Stowe

Neurotherapeutics, Vol.13(4), pp.729-747

10/2016

DOI: 10.1007/s13311-016-0460-4

PMCID: PMC5081124

PMID: 27492770

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Abstract

It is well established that post-stroke inflammation contributes to neurovascular injury, blood-brain barrier disruption, and poor functional recovery in both animal and clinical studies. However, recent studies also suggest that several leukocyte subsets, activated during the post-stroke immune response, can exhibit both pro-injury and pro-recovery phenotypes. In accordance with these findings, B lymphocytes, or B cells, play a heterogeneous role in the adaptive immune response to stroke. This review highlights what is currently understood about the various roles of B cells, with an emphasis on stroke risk factors, as well as post-stroke injury and repair. This includes an overview of B cell functions, such as antibody production, cytokine secretion, and contribution to the immune response as antigen presenting cells. Next, evidence for B cell-mediated mechanisms in stroke-related risk factors, including hypertension, diabetes, and atherosclerosis, is outlined, followed by studies that focus on B cells during endogenous protection from stroke. Subsequently, animal studies that investigate the role of B cells in post-stroke injury and repair are summarized, and the final section describes current B cell-related clinical trials for stroke, as well as other central nervous system diseases. This review reveals the complex role of B cells in stroke, with a focus on areas for potential clinical intervention for a disease that affects millions of people globally each year.

Stroke - pathology

Stroke - prevention & control

Animals

Humans

B-Lymphocytes - physiology

Stroke - complications

Stroke - immunology

Details

Title: Subtitle: Heterogeneity of B Cell Functions in Stroke-Related Risk, Prevention, Injury, and Repair
Creators: Uma Maheswari Selvaraj - Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, 6000 Harry Hines Blvd, MC8813, Dallas, TX, 75390, USA
Katherine Poinsatte - Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, 6000 Harry Hines Blvd, MC8813, Dallas, TX, 75390, USA
Vanessa Torres - Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, 6000 Harry Hines Blvd, MC8813, Dallas, TX, 75390, USA
Sterling B Ortega - Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, 6000 Harry Hines Blvd, MC8813, Dallas, TX, 75390, USA
Ann M Stowe - Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, 6000 Harry Hines Blvd, MC8813, Dallas, TX, 75390, USA. Ann.Stowe@utsouthwestern.edu
Resource Type: Journal article
Publication Details: Neurotherapeutics, Vol.13(4), pp.729-747
DOI: 10.1007/s13311-016-0460-4
PMID: 27492770
PMCID: PMC5081124
NLM abbreviation: Neurotherapeutics
ISSN: 1933-7213
eISSN: 1878-7479
Publisher: United States
Grant note: R01 NS088555 / NINDS NIH HHS
Language: English
Date published: 10/2016
Academic Unit: Pathology
Record Identifier: 9984065488102771

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