Journal article
Heterogeneity of Hereditary Hearing Loss in Iran: a Comprehensive Review
Archives of Iranian medicine, Vol.19(10), pp.720-728
10/01/2016
PMCID: PMC5541368
PMID: 27743438
Abstract
A significant contribution to the causes of hereditary hearing impairment comes from genetic factors. More than 120 genes and 160 loci have been identified to be involved in hearing impairment. Given that consanguine populations are more vulnerable to most inherited diseases, such as hereditary hearing loss (HHL), the genetic picture of HHL among the Iranian population, which consists of at least eight ethnic subgroups with a high rate of intermarriage, is expected to be highly heterogeneous. Using an electronic literature review through various databases such as PubMed, MEDLINE, and Scopus, we review the current picture of HHL in Iran. In this review, we present more than 39 deafness genes reported to cause non-syndromic HHL in Iran, of which the most prevalent causative genes include GJB2, SLC26A4, MYO15A, and MYO7A. In addition, we highlight some of the more common genetic causes of syndromic HHL in Iran. These results are of importance for further investigation and elucidation of the molecular basis of HHL in Iran and also for developing a national diagnostic tool tailored to the Iranian context enabling early and efficient diagnosis of hereditary hearing impairment.
Details
- Title: Subtitle
- Heterogeneity of Hereditary Hearing Loss in Iran: a Comprehensive Review
- Creators
- Maryam Beheshtian - Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranMojgan Babanejad - Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranHela Azaiez - Department of Otolaryngology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USANiloofar Bazazzadegan - Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranDiana Kolbe - Department of Otolaryngology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAChristina Sloan-Heggen - Department of Otolaryngology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USASanaz Arzhangi - Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranKevin Booth - Department of Otolaryngology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAMarzieh Mohseni - Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranKathy Frees - Department of Otolaryngology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAMohammad Hossein Azizi - Academy of Medical Sciences Islamic Republic of Iran, Tehran, IranAhmad Daneshi - Head and Neck Surgery Department and Research Center, Iran University of Medical Sciences, Tehran, IranMohammad Farhadi - Head and Neck Surgery Department and Research Center, Iran University of Medical Sciences, Tehran, IranKimia Kahrizi - Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranRichard Jh Smith - Department of Otolaryngology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAHossein Najmabadi - Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
- Resource Type
- Journal article
- Publication Details
- Archives of Iranian medicine, Vol.19(10), pp.720-728
- PMID
- 27743438
- PMCID
- PMC5541368
- NLM abbreviation
- Arch Iran Med
- ISSN
- 1029-2977
- eISSN
- 1735-3947
- Publisher
- Iran
- Grant note
- R01 DC003544 / NIDCD NIH HHS R01 DC012049 / NIDCD NIH HHS R01 DC002842 / NIDCD NIH HHS T32 GM007337 / NIGMS NIH HHS
- Language
- English
- Date published
- 10/01/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine; Iowa Institute of Human Genetics
- Record Identifier
- 9984007184702771
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