Journal article
Heterogeneity of anti-idiotypic antibodies to anti-DNA antibodies in humans
Clinical and experimental immunology, Vol.71(1), pp.67-72
01/01/1988
PMCID: PMC1541633
PMID: 3258206
Abstract
Serum antibodies in some patients with systemic lupus erythematosus (SLE) were found to have specificity to idiotypes (Id) of 0-81 (human monoclonal anti-single-stranded DNA (ssDNA) antibody) but not to Id of NE-1 (human monoclonal anti-double-stranded DNA (dsDNA) antibody) or pooled human IgM. The interaction of the antibodies and 0-81 was blocked by the co-existence of free ssDNA. Some of SLE sera also showed preferential binding to Id determinants of NE-1, which included the antigen-binding sites of the dsDNA antibody. Some other SLE sera reacted with both Id of 0-81 and NE-13. Thus, there was heterogeneous population among human anti-Id autoantibodies to anti-DNA antibodies. The anti-Id activity was commonly detected in inactive SLE sera, and less frequently in normal controls, suggesting some regulatory role for anti-Id antibodies in the production of autoantibodies.
Details
- Title: Subtitle
- Heterogeneity of anti-idiotypic antibodies to anti-DNA antibodies in humans
- Creators
- T Muryoi - Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, JapanT Sasaki - Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, JapanN Harata - Tohoku UniversityO Takai - Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, JapanE Tamate - Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, JapanK Yoshinaga - Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
- Resource Type
- Journal article
- Publication Details
- Clinical and experimental immunology, Vol.71(1), pp.67-72
- PMID
- 3258206
- PMCID
- PMC1541633
- ISSN
- 0009-9104
- eISSN
- 1365-2249
- Language
- English
- Date published
- 01/01/1988
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984297605502771
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