Journal article
Heteromultimeric Interactions among K + Channel Subunits from Shaker and eag Families in Xenopus Oocytes
Neuron (Cambridge, Mass.), Vol.17(3), pp.535-542
1996
DOI: 10.1016/S0896-6273(00)80185-3
PMID: 8816716
Abstract
Heteromultimeric interactions of K
+ channel subunits across different families have been thought to contribute to the functional diversity of ionic currents, as suggested by previous genetic evidence. We present here direct demonstration in Xenopus oocytes that subunits from distinct
eag and
Shaker families functionally interact, most likely as heteromultimeric channels. Coexpression with
eag accelerates the inactivation and slows the recovery from inactivation of the transient
Shaker current. Site-directed mutagenesis indicates that the
eag carboxyl terminus is crucial for this interaction, exerting effects preferentially on N-type inactivation. Many members of the
eag and
Shaker families have now been identified and their human homologs implicated in cardiac and neurological disorders. Studies on channel subunit interactions may prove important in understanding the disease pattern and the complex functions of the brain.
Details
- Title: Subtitle
- Heteromultimeric Interactions among K + Channel Subunits from Shaker and eag Families in Xenopus Oocytes
- Creators
- Mai-Lei Chen - Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242, USAToshinori Hoshi - Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USAChun-Fang Wu - Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242, USA
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.17(3), pp.535-542
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0896-6273(00)80185-3
- PMID
- 8816716
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Language
- English
- Date published
- 1996
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984070784102771
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