Journal article
Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus
Neuron (Cambridge, Mass.), Vol.96(1), pp.160-176.e8
09/27/2017
DOI: 10.1016/j.neuron.2017.09.009
PMCID: PMC5634529
PMID: 28957665
Abstract
Hippocampal CA3 neurons form synapses with CA1 neurons in two layers, stratum oriens (SO) and stratum radiatum (SR). Each layer develops unique synaptic properties but molecular mechanisms that mediate these differences are unknown. Here, we show that SO synapses normally have significantly more mushroom spines and higher-magnitude long-term potentiation (LTP) than SR synapses. Further, we discovered that these differences require the Type II classic cadherins, cadherins-6, -9, and -10. Though cadherins typically function via trans-cellular homophilic interactions, our results suggest presynaptic cadherin-9 binds postsynaptic cadherins-6 and -10 to regulate mushroom spine density and high-magnitude LTP in the SO layer. Loss of these cadherins has no effect on the lower-magnitude LTP typically observed in the SR layer, demonstrating that cadherins-6, -9, and -10 are gatekeepers for high-magnitude LTP. Thus, Type II cadherins may uniquely contribute to the specificity and strength of synaptic changes associated with learning and memory.
•CA1 neurons have layer-specific differences in LTP magnitude•Cadherin-9, expressed in CA3 neurons, binds cadherins-6 and -10, expressed in CA1 neurons•Cadherins-6, -9, and -10 are specifically required for high-magnitude LTP
Basu et al. demonstrate that different synaptic layers of hippocampal CA1 neurons have distinct synaptic potentiation properties and three heterophilic cadherins, cadherins-6, -9, and -10, are required for normal mushroom spine density and high-magnitude LTP specifically in CA1 basal dendrites.
Details
- Title: Subtitle
- Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus
- Creators
- Raunak Basu - University of UtahXin Duan - University of California, San FranciscoMatthew R. Taylor - University of UtahE Anne Martin - University of UtahShruti Muralidhar - University of UtahYueqi Wang - University of UtahLuke Gangi-Wellman - University of UtahSujan C. Das - University of UtahMasahito Yamagata - Harvard UniversityPeter J. West - University of UtahJoshua R. Sanes - Harvard UniversityMegan E. Williams - University of Utah
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.96(1), pp.160-176.e8
- DOI
- 10.1016/j.neuron.2017.09.009
- PMID
- 28957665
- PMCID
- PMC5634529
- NLM abbreviation
- Neuron
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 09/27/2017
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984937941602771
Metrics
2 Record Views