Journal article
Heterotransplantation of human choroidal melanoma into the athymic "nude" mouse
Investigative ophthalmology & visual science, Vol.19(5), pp.555-559
05/1980
PMID: 7372416
Abstract
The investigation of the structure and behavior of malignant melanoma of the uveal tract in man has been limited by the lack of a ready source of human tumor and an animal model in which the tumor resembles that in the human choroid. We now report the observation that fresh surgical specimens of human choroidal melanoma can be successfully transplanted into the posterior segment of the "nude" mouse (a homozygous mutant, nu/nu, with a defect in cellular immunity) and can be serially transplanted. This model utilizing human melanoma should be useful for the study of the natural history of this disease, as well as the response to various chemotherapeutic agents.
Details
- Title: Subtitle
- Heterotransplantation of human choroidal melanoma into the athymic "nude" mouse
- Creators
- D M AlbertM D WagonerK MoazedG P KimballJ R Gonder
- Resource Type
- Journal article
- Publication Details
- Investigative ophthalmology & visual science, Vol.19(5), pp.555-559
- Publisher
- United States
- PMID
- 7372416
- ISSN
- 0146-0404
- eISSN
- 1552-5783
- Language
- English
- Date published
- 05/1980
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983979925402771
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