HeyL promotes neuronal differentiation of neural progenitor cells

Ali Jalali; Alexander G Bassuk; Lixin Kan; Nipan Israsena; Abhishek Mukhopadhyay; Tammy McGuire; John A Kessler

doi:10.1002/jnr.22562

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HeyL promotes neuronal differentiation of neural progenitor cells

Journal article

Peer reviewed

HeyL promotes neuronal differentiation of neural progenitor cells

Ali Jalali, Alexander G Bassuk, Lixin Kan, Nipan Israsena, Abhishek Mukhopadhyay, Tammy McGuire and John A Kessler

Journal of neuroscience research, Vol.89(3), pp.299-309

03/2011

DOI: 10.1002/jnr.22562

PMCID: PMC3079914

PMID: 21259317

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https://www.ncbi.nlm.nih.gov/pmc/articles/3079914View

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Abstract

Members of the Hes and Hey families of basic helix-loop-helix transcription factors are regarded as Notch target genes that generally inhibit neuronal differentiation of neural progenitor cells. We found that HeyL, contrary to the classic function of Hes and Hey factors, promotes neuronal differentiation of neural progenitor cells both in culture and in the embryonic brain in vivo . Further, null mutation of HeyL decreased the rate of neuronal differentiation of cultured neural progenitor cells. HeyL binds to and activates the promoter of the proneural gene neurogenin2, which is inhibited by other Hes and Hey family members, and HeyL is a weak inhibitor of the Hes1 promoter. HeyL is able to bind other Hes and Hey family members, but it cannot bind the Groucho/Tle1 transcriptional co-repressor which mediates the inhibitory effects of the Hes family of factors. Further, while HeyL expression is only weakly augmented by Notch signaling, we found that BMP signaling increases HeyL expression by neural progenitor cells. These observations suggest that HeyL promotes neuronal differentiation of neural progenitor cells by activating proneural genes and by inhibiting the actions of other Hes and Hey family members.

neural stem cell

Neurogenesis

Hey

Hes

Notch

Details

Title: Subtitle: HeyL promotes neuronal differentiation of neural progenitor cells
Creators: Ali Jalali - Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Alexander G Bassuk - Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Lixin Kan - Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Nipan Israsena - Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Abhishek Mukhopadhyay - Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Tammy McGuire - Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
John A Kessler - Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Resource Type: Journal article
Publication Details: Journal of neuroscience research, Vol.89(3), pp.299-309
DOI: 10.1002/jnr.22562
PMID: 21259317
PMCID: PMC3079914
NLM abbreviation: J Neurosci Res
ISSN: 0360-4012
eISSN: 1097-4547
Language: English
Date published: 03/2011
Academic Unit: Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
Record Identifier: 9984013920702771

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