High-Grade Squamous Intraepithelial Lesion of the Gastroesophageal Junction Secondary to High-Risk Human Papillomavirus

Edward B Stelow; Erik A Dill; Jonathan J Davick; Michael B McCabe; Vanessa M Shami

doi:10.1093/ajcp/aqz039

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High-Grade Squamous Intraepithelial Lesion of the Gastroesophageal Junction Secondary to High-Risk Human Papillomavirus

Journal article

Open access

Peer reviewed

High-Grade Squamous Intraepithelial Lesion of the Gastroesophageal Junction Secondary to High-Risk Human Papillomavirus

Edward B Stelow, Erik A Dill, Jonathan J Davick, Michael B McCabe and Vanessa M Shami

American journal of clinical pathology, Vol.152(3), pp.359-364

08/01/2019

DOI: 10.1093/ajcp/aqz039

PMID: 31216362

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Abstract

Although the role of human papillomavirus (HPV) in the development of some carcinomas (eg, anogenital and oropharyngeal squamous cell carcinomas) is nondebatable, there is still significant controversy regarding the relationship of HPV and esophageal squamous cell carcinomas (SCCs). All cases were sampled at or near the gastroesophageal junctions in patients with reflux and/or known Barrett esophagus and appear to have been initially sampled "incidentally." Patients were all men, aged 56 to 80 years. None had a known history of other HPV-related disease. We present four cases of high-grade squamous intraepithelial lesion of the gastroesophageal junction secondary to high-risk HPV that have identical histologic features to similar lesions of the anogenital tract. Whether such lesions are at risk for developing into invasive SCC remains unclear.

Aged, 80 and over

Esophageal Diseases - pathology

Esophageal Diseases - virology

Esophagogastric Junction - pathology

Esophagogastric Junction - virology

Humans

Male

Middle Aged

Papillomaviridae

Papillomavirus Infections - complications

Squamous Intraepithelial Lesions - pathology

Squamous Intraepithelial Lesions - virology

Details

Title: Subtitle: High-Grade Squamous Intraepithelial Lesion of the Gastroesophageal Junction Secondary to High-Risk Human Papillomavirus
Creators: Edward B Stelow - University of Virginia
Erik A Dill - University of Virginia
Jonathan J Davick - University of Virginia
Michael B McCabe - University of Virginia
Vanessa M Shami - University of Virginia
Resource Type: Journal article
Publication Details: American journal of clinical pathology, Vol.152(3), pp.359-364
DOI: 10.1093/ajcp/aqz039
PMID: 31216362
NLM abbreviation: Am J Clin Pathol
ISSN: 0002-9173
eISSN: 1943-7722
Language: English
Date published: 08/01/2019
Academic Unit: Pathology
Record Identifier: 9984186387402771

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