Journal article
High-Intensity Exercise Enhances Conduit Artery Vascular Function in Older Adults
Medicine and science in sports and exercise, Vol.50(1), pp.124-130
01/2018
DOI: 10.1249/MSS.0000000000001405
PMCID: PMC5735000
PMID: 28817509
Abstract
PURPOSEModulation of vascular function follows an exercise intensity–dependent pattern in young adults. This study aimed to investigate the potential intensity–dependent effects of an acute bout of exercise on conduit and resistance artery function in healthy older adults.
METHODSEleven healthy older adults (five males/six females, 66 ± 1 yr) completed 30 min of recumbent cycling at 50%–55% (low intensity) and 75%–80% (high intensity) of their age-predicted HRmax on two separate study visits. Doppler ultrasound measures of brachial artery flow-mediated dilation (FMD) and reactive hyperemia were taken at baseline, 10 min postexercise, and 1 h postexercise. In addition, cardiovascular hemodynamics and brachial shear rate were measured every 5 min during exercise.
RESULTSBrachial artery FMD was enhanced 10 min after high-intensity exercise (4.8% ± 0.2% to 9.1% ± 0.3%, P < 0.01), but not low-intensity (4.7% ± 0.2% to 6.2% ± 0.3%, P = 0.54) exercise. Peak and total (area under the curve) blood flow during reactive hyperemia (measures of resistance artery function) were enhanced 10 min postexercise for both intensities (peak low intensity, 372 ± 31 to 444 ± 37 mL·min; peak high intensity, 391 ± 30 to 455 ± 28 mL·min; total low intensity, 142 ± 16 to 205 ± 20 mL; total high intensity, 158 ± 14 to 240 ± 25 mL; main effect of time for both, P < 0.05). However, the magnitude of change in peak and the total blood flow were not different between exercise intensities (interaction effect; P = 0.56 and P = 0.97, respectively). Independent of exercise intensity, FMD returned to baseline 1 h after exercise (high, 5.9% ± 0.3%; low, 5.1% ± 0.1%; both P > 0.05).
CONCLUSIONOur data indicate that high-intensity exercise acutely enhances conduit artery function in healthy older adults. In addition, an acute bout of exercise enhances resistance artery function independent of intensity.
Details
- Title: Subtitle
- High-Intensity Exercise Enhances Conduit Artery Vascular Function in Older Adults
- Creators
- ERIKA IWAMOTO - Human Integrative and Cardiovascular Physiology Laboratory, Department of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IAJOSHUA BOCK - Human Integrative and Cardiovascular Physiology Laboratory, Department of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IADARREN CASEY - Human Integrative and Cardiovascular Physiology Laboratory, Department of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- Medicine and science in sports and exercise, Vol.50(1), pp.124-130
- DOI
- 10.1249/MSS.0000000000001405
- PMID
- 28817509
- PMCID
- PMC5735000
- NLM abbreviation
- Med Sci Sports Exerc
- ISSN
- 0195-9131
- eISSN
- 1530-0315
- Publisher
- American College of Sports Medicine
- Language
- English
- Date published
- 01/2018
- Academic Unit
- Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984047638002771
Metrics
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