Journal article
High-Intensity Physical Activity During Late Adolescence Predicts Young Adult CT-Based Finite Element Bone Strength in Emerging Adulthood: Iowa Bone Development Study
Children (Basel), Vol.12(9), 1204
09/09/2025
DOI: 10.3390/children12091204
PMCID: PMC12468735
PMID: 41007069
Abstract
Objective: This study investigated associations between physical activity (PA) during late adolescence and emerging adulthood and bone strength in emerging adulthood by utilizing advanced finite element analysis of computed tomography (CT/FEA) technology beyond the traditional dual-energy X-ray absorptiometry (DXA) method. Methods: This study included 266 participants (152 females) from the Iowa Bone Development Study. PA volume (average acceleration) and intensity (intensity gradient) metrics were calculated from ActiGraph accelerometer data collected at ages 17, 19, 21, and 23 years. Compressive modulus and compressive stiffness of the tibia were estimated at age 23 via CT/FEA of the tibia. Sex-specific linear regression models were used to evaluate associations between PA metrics and bone outcomes, adjusting for age, height, weight, musculoskeletal fitness, and calcium intake. Results: Intensity gradient averaged over 17–23 years of age was positively associated with compressive stiffness at age 23 years in both females and males (p < 0.01). Intensity gradient was positively associated with compressive modulus in females (p < 0.01), but not in males. No significant associations were found between average acceleration and either compressive stiffness or modulus in either sex (p > 0.05). Conclusions: Using a state-of-the-art CT/FEA method, this study suggests that high-intensity PA during late adolescence and emerging adulthood improves bone strength.
Details
- Title: Subtitle
- High-Intensity Physical Activity During Late Adolescence Predicts Young Adult CT-Based Finite Element Bone Strength in Emerging Adulthood: Iowa Bone Development Study
- Creators
- Soyang Kwon - Northwestern UniversityKathleen F. Janz - University of IowaIndranil Guha - University of IowaAlex V. Rowlands - University of South AustraliaOscar Rysavy - University of IowaPunam K. Saha - University of IowaChandler Pendleton - University of IowaEuisung D. ShinSteven M. Levy - University of Iowa, Preventive and Community Dentistry
- Resource Type
- Journal article
- Publication Details
- Children (Basel), Vol.12(9), 1204
- DOI
- 10.3390/children12091204
- PMID
- 41007069
- PMCID
- PMC12468735
- NLM abbreviation
- Children (Basel)
- ISSN
- 2227-9067
- eISSN
- 2227-9067
- Publisher
- MDPI
- Grant note
- National Institute of Child Health and DevelopmentNational Institute of Dental and Craniofacial Research: R01-DE12101, R01-DE09551 National Center for Research Resources: UL1 RR024979, M01-RR00059
This research was supported by National Institute of Child Health and Development (R03HD100657), the National Institute of Dental and Craniofacial Research (R01-DE12101, R01-DE09551), and the National Center for Research Resources (UL1 RR024979, M01-RR00059).
- Language
- English
- Date published
- 09/09/2025
- Academic Unit
- Preventive and Community Dentistry; Electrical and Computer Engineering; Epidemiology; Dental Research; Health, Sport, and Human Physiology
- Record Identifier
- 9984962543602771
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