Journal article
High Levels of NfL, GFAP, TAU, and UCH-L1 as Potential Predictor Biomarkers of Severity and Lethality in Acute COVID-19
Molecular neurobiology, Vol.61(6), pp.3545-3558
06/01/2024
DOI: 10.1007/s12035-023-03803-z
PMID: 37996731
Abstract
Few studies showed that neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), total tubulin-associated unit (TAU), and ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) may be related to neurological manifestations and severity during and after SARS-CoV-2 infection. The objective of this work was to investigate the relationship among nervous system biomarkers (NfL, TAU, GFAP, and UCH-L1), biochemical parameters, and viral loads with heterogeneous outcomes in a cohort of severe COVID-19 patients admitted in Intensive Care Unit (ICU) of a university hospital. For that, 108 subjects were recruited within the first 5 days at ICU. In parallel, 16 mild COVID-19 patients were enrolled. Severe COVID-19 group was divided between "deceased" and "survivor." All subjects were positive for SARS-CoV-2 detection. NfL, total TAU, GFAP, and UCH-L1 quantification in plasma was performed using SIMOA SR-X platform. Of 108 severe patients, 36 (33.33%) presented neurological manifestation and 41 (37.96%) died. All four biomarkers - GFAP, NfL, TAU, and UCH-L1 - were significantly higher among deceased patients in comparison to survivors (p < 0.05). Analyzing biochemical biomarkers, higher Peak Serum Ferritin, D-Dimer Peak, Gamma-glutamyltransferase, and C-Reactive Protein levels were related to death (p < 0.0001). In multivariate analysis, GFAP, NfL, TAU, UCH-L1, and Peak Serum Ferritin levels were correlated to death. Regarding SARS-CoV-2 viral load, no statistical difference was observed for any group. Thus, Ferritin, NFL, GFAP, TAU, and UCH-L1 are early biomarkers of severity and lethality of SARS-COV-2 infection and may be important tools for therapeutic decision-making in the acute phase of disease.
Details
- Title: Subtitle
- High Levels of NfL, GFAP, TAU, and UCH-L1 as Potential Predictor Biomarkers of Severity and Lethality in Acute COVID-19
- Creators
- Andreza Lemos Salvio - Universidade Federal do Estado do Rio de JaneiroRenan Amphilophio Fernandes - Universidade Federal do Estado do Rio de JaneiroHelena França Alcaraz Ferreira - Laboratory of Translacional Neurosciences, Biomedical Institute, Federal University of the State of Rio de Janeiro-UNIRIO, Rio de Janeiro, 22290-240, BrazilLarissa Araujo Duarte - Universidade Federal do Estado do Rio de JaneiroElisa Gouvea Gutman - Universidade Federal do Estado do Rio de JaneiroJessica Vasques Raposo-Vedovi - Universidade Federal do Estado do Rio de JaneiroCarlos Henrique Ferreira Ramos Filho - Universidade Federal do Rio de JaneiroWagner Luis da Costa Nunes Pimentel Coelho - Fundação Oswaldo CruzGiselle Fazzioni Passos - Universidade Federal do Rio de JaneiroMaria Emília Cosenza Andraus - Universidade Federal do Rio de JaneiroJoão Paulo da Costa Gonçalves - Universidade Federal do Estado do Rio de JaneiroMarta Guimarães Cavalcanti - Universidade Federal do Rio de JaneiroMarisa Pimentel Amaro - Universidade Federal do Rio de JaneiroRafael Kader - Universidade Federal do Rio de JaneiroRoberto de Andrade Medronho - Universidade Federal do Rio de JaneiroCláudia Pinto Figueiredo - Universidade Federal do Rio de JaneiroLuciane Almeida Amado-Leon - Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-901, Brazil. luciane.amado.fiocruz@gmail.comSoniza Vieira Alves-Leon - Universidade Federal do Rio de Janeiro
- Resource Type
- Journal article
- Publication Details
- Molecular neurobiology, Vol.61(6), pp.3545-3558
- DOI
- 10.1007/s12035-023-03803-z
- PMID
- 37996731
- NLM abbreviation
- Mol Neurobiol
- ISSN
- 0893-7648
- eISSN
- 1559-1182
- Grant note
- E-26/201.040/2021 / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E26/206.022/2022 / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro VPPCB-005-FIO-20-2-56 / Fundação Oswaldo Cruz E26/210.254/2020 / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/200.733/2021 / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/201.406/2021 / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/210.273/2018 / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/210.657/2021 / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Language
- English
- Date published
- 06/01/2024
- Academic Unit
- Neurology
- Record Identifier
- 9985180933202771
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