High Prevalence of Hepatitis B Virus Pre-S Mutant in Countries Where It Is Endemic and Its Relationship with Genotype and Chronicity

Tran Thien-Tuan Huy; Hiroshi Ushijima; Khin Maung Win; Pairoj Luengrojanakul; Pradeep Krishna  Shrestha; Zhao-Hua Zhong; Andrei V Smirnov; Teresa Casanovas Taltavull; Tetsutaro Sata; Kenji Abe

doi:10.1128/JCM.41.12.5449-5455.2003

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High Prevalence of Hepatitis B Virus Pre-S Mutant in Countries Where It Is Endemic and Its Relationship with Genotype and Chronicity

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High Prevalence of Hepatitis B Virus Pre-S Mutant in Countries Where It Is Endemic and Its Relationship with Genotype and Chronicity

Tran Thien-Tuan Huy, Hiroshi Ushijima, Khin Maung Win, Pairoj Luengrojanakul, Pradeep Krishna Shrestha, Zhao-Hua Zhong, Andrei V Smirnov, Teresa Casanovas Taltavull, Tetsutaro Sata and Kenji Abe

Journal of clinical microbiology, Vol.41(12), pp.5449-5455

12/2003

DOI: 10.1128/JCM.41.12.5449-5455.2003

PMCID: PMC308995

PMID: 14662924

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Abstract

It has been reported that hepatitis B virus (HBV) mutants carrying mutations in the pre-S region can be found in infected patients. In this study, we investigated the prevalence of the HBV variant with the pre-S mutant in different geographic regions, including countries with low and high levels of endemic HBV infection, and analyzed the correlation with clinical findings. We examined 387 HBV DNA-positive serum samples from individuals among 12 countries, consisting of Vietnam, Myanmar, Thailand, China, Korea, Nepal, Japan, Russia, Spain, United States, Bolivia, and Ghana. HBV pre-S mutants were detected in 71 (18.3%) of 387 serum samples tested. This mutant was the most prevalent in Vietnam (36%), followed by Nepal (27.3%), Myanmar (23.3%), China (22.4%), Korea (14.3%), Thailand (10.5%), Japan (7.7%), and Ghana (4.3%). In contrast, no case with this mutation was found in Russia, Spain, United States, and Bolivia. Among the HBV deletion mutations, 15.5% (11 of 71) occurred in the pre-S1 and 46.5% (33 of 71) in the pre-S2 regions. Eight (11.3%) cases had a mutation in both the pre-S1 and pre-S2 regions. In addition, a point mutation at the pre-S2 starting codon was observed in 19 (26.7%) cases. The detection rate of the HBV mutant in patients with hepatocellular carcinoma was significantly higher than in other patients ( P < 0.05). Furthermore, these mutants were found more frequently in genotype B (25%) and genotype C (24.5%) than in the other genotypes ( P < 0.05). Our results indicated that there was a high prevalence of HBV pre-S mutation in regions of endemic HBV infection in Asia. Furthermore, the pre-S mutation appeared to be correlated with hepatocellular carcinoma and HBV genotypes.

Virology

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Title: Subtitle: High Prevalence of Hepatitis B Virus Pre-S Mutant in Countries Where It Is Endemic and Its Relationship with Genotype and Chronicity
Creators: Tran Thien-Tuan Huy - Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
Hiroshi Ushijima - Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
Khin Maung Win - Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
Pairoj Luengrojanakul - Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
Pradeep Krishna Shrestha - Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
Zhao-Hua Zhong - Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
Andrei V Smirnov - Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
Teresa Casanovas Taltavull - Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
Tetsutaro Sata - Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
Kenji Abe - Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
Resource Type: Journal article
Publication Details: Journal of clinical microbiology, Vol.41(12), pp.5449-5455
DOI: 10.1128/JCM.41.12.5449-5455.2003
PMID: 14662924
PMCID: PMC308995
NLM abbreviation: J Clin Microbiol
ISSN: 0095-1137
eISSN: 1098-660X
Publisher: American Society for Microbiology
Language: English
Date published: 12/2003
Academic Unit: Gastroenterology and Hepatology; Internal Medicine
Record Identifier: 9984094326502771

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