Journal article
High-Risk Human Papillomavirus Reactivation in Human Immunodeficiency Virus-Infected Women: Risk Factors for Cervical Viral Shedding
Obstetrics and gynecology (New York. 1953), Vol.115(6), pp.1150-1158
06/01/2010
DOI: 10.1097/AOG.0b013e3181e00927
PMID: 20502284
Abstract
OBJECTIVE:
To evaluate the presence of and estimate risk factors for reactivation of latent high-risk human papillomavirus (HPV) cervical infection in human immunodeficiency virus (HIV)-infected and HIV-uninfected women.
METHODS:
Data from 898 women in the HIV Epidemiology Research Study (HERS) were used to evaluate cervical HPV latency and reactivation. Prior exposure to HPV types (16, 18, 31, 35, and 45) was determined by serologic testing at enrollment, and cervical shedding of HPV was detected by polymerase chain reaction at 6-month intervals. Human papillomavirus cervical shedding and sexual history were used to estimate rates of reactivation and recurrence. Repeated measures survival analysis was used to estimate hazard ratios and 95% confidence intervals for reactivation and recurrence. Rates of total HPV shedding (recurrence and reactivation) during follow-up were assessed by HIV status and rate ratios were calculated.
RESULTS:
Reactivation of latent HPV infections was observed in HIV-infected women, but few reactivation events were identified in HIV-uninfected women. Factors consistently associated with reactivation in HIV-infected women included CD4 count less than 200/mm3 and age younger than 35 years. Women infected with HIV had 1.8 to 8.2 times higher rates of viral shedding (reactivation plus recurrence) compared with HIV-uninfected women.
CONCLUSION:
Women with a history of cervical HPV infection may be at risk of reactivation of latent viral infection even in the absence of sexual activity, and this risk is higher in women with HIV infection.
Details
- Title: Subtitle
- High-Risk Human Papillomavirus Reactivation in Human Immunodeficiency Virus-Infected Women: Risk Factors for Cervical Viral Shedding
- Creators
- Regan N Theiler - The University of Texas Medical Branch at GalvestonSherry L Farr - The University of Texas Medical Branch at GalvestonDenise J Jamieson - The University of Texas Medical Branch at GalvestonJohn M Karon - The University of Texas Medical Branch at GalvestonPangaja Paramsothy - The University of Texas Medical Branch at GalvestonRaphael Viscidi - The University of Texas Medical Branch at GalvestonAnn Duerr - Centers for Disease Control and PreventionSusan CU-UVIN - The University of Texas Medical Branch at GalvestonJack Sobel - Wayne State UniversityKeerti Shah - Johns Hopkins UniversityRobert S Klein - Icahn School of Medicine at Mount Sinai
- Resource Type
- Journal article
- Publication Details
- Obstetrics and gynecology (New York. 1953), Vol.115(6), pp.1150-1158
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/AOG.0b013e3181e00927
- PMID
- 20502284
- ISSN
- 0029-7844
- eISSN
- 1873-233X
- Language
- English
- Date published
- 06/01/2010
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446420202771
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