Journal article
High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study
The European respiratory journal, Vol.48(5), pp.1442-1452
11/2016
DOI: 10.1183/13993003.00129-2016
PMCID: PMC5089905
PMID: 27471206
Abstract
Evidence suggests that lung injury, inflammation and extracellular matrix remodelling precede lung fibrosis in interstitial lung disease (ILD). We examined whether a quantitative measure of increased lung attenuation on computed tomography (CT) detects lung injury, inflammation and extracellular matrix remodelling in community-dwelling adults sampled without regard to respiratory symptoms or smoking.We measured high attenuation areas (HAA; percentage of lung voxels between -600 and -250 Hounsfield Units) on cardiac CT scans of adults enrolled in the Multi-Ethnic Study of Atherosclerosis.HAA was associated with higher serum matrix metalloproteinase-7 (mean adjusted difference 6.3% per HAA doubling, 95% CI 1.3-11.5), higher interleukin-6 (mean adjusted difference 8.8%, 95% CI 4.8-13.0), lower forced vital capacity (FVC) (mean adjusted difference -82 mL, 95% CI -119--44), lower 6-min walk distance (mean adjusted difference -40 m, 95% CI -1--80), higher odds of interstitial lung abnormalities at 9.5 years (adjusted OR 1.95, 95% CI 1.43-2.65), and higher all cause-mortality rate over 12.2 years (HR 1.58, 95% CI 1.39-1.79).High attenuation areas are associated with biomarkers of inflammation and extracellular matrix remodelling, reduced lung function, interstitial lung abnormalities, and a higher risk of death among community-dwelling adults.
Details
- Title: Subtitle
- High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study
- Creators
- Anna J Podolanczuk - Both authors contributed equally to this workElizabeth C Oelsner - Both authors contributed equally to this workR Graham Barr - Dept of Epidemiology, Columbia University Medical Center, New York, NY, USAEric A Hoffman - Depts of Radiology, Medicine and Biomedical Engineering, University of Iowa Carver College of Medicine, Iowa City, IA, USAHilary F Armstrong - Dept of Epidemiology, Columbia University Medical Center, New York, NY, USAJohn H M Austin - Dept of Radiology, Columbia University Medical Center, New York, NY, USARobert C Basner - Dept of Medicine, Columbia University Medical Center, New York, NY, USAMatthew N Bartels - Dept of Rehabilitation Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USAJason D Christie - Dept of Medicine and the Center for Translational Lung Biology, University of Pennsylvania, Philadelphia, PA, USAPaul L Enright - Dept of Epidemiology, University of Arizona, Tucson, AZ, USABernadette R Gochuico - National Human Genome Research Institute, Bethesda, MD, USAKaren Hinckley Stukovsky - Dept of Biostatistics, University of Washington, Seattle, WA, USAJoel D Kaufman - Dept of Medicine, University of Washington, Seattle, WA, USAP Hrudaya Nath - Dept of Radiology, University of Alabama, South Birmingham, AL, USAJohn D Newell Jr - Depts of Radiology, Medicine and Biomedical Engineering, University of Iowa Carver College of Medicine, Iowa City, IA, USAScott M Palmer - Duke Clinical Research Institute, Duke University, Durham, NC, USADan Rabinowitz - Dept of Statistics, Columbia University, New York, NY, USAGanesh Raghu - Dept of Medicine, University of Washington, Seattle, WA, USAJessica L Sell - Dept of Medicine, Columbia University Medical Center, New York, NY, USAJered Sieren - VIDA Diagnostics, Inc., Coralville, IA, USASushil K Sonavane - Dept of Radiology, University of Alabama, South Birmingham, AL, USARussell P Tracy - Dept of Pathology, University of Vermont, Colchester, VT, USAJubal R Watts - Dept of Radiology, University of Alabama, South Birmingham, AL, USAKayleen Williams - Dept of Medicine, University of Washington, Seattle, WA, USASteven M Kawut - Dept of Medicine and the Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USADavid J Lederer - Dept of Epidemiology, Columbia University Medical Center, New York, NY, USA
- Resource Type
- Journal article
- Publication Details
- The European respiratory journal, Vol.48(5), pp.1442-1452
- Publisher
- England
- DOI
- 10.1183/13993003.00129-2016
- PMID
- 27471206
- PMCID
- PMC5089905
- ISSN
- 0903-1936
- eISSN
- 1399-3003
- Grant note
- N01HC95169 / NHLBI NIH HHS N01 HC095160 / NHLBI NIH HHS N01HC95161 / NHLBI NIH HHS N01 HC095168 / NHLBI NIH HHS T32 HL105323 / NHLBI NIH HHS N01 HC095165 / NHLBI NIH HHS N01HC95164 / NHLBI NIH HHS N01HC95167 / NHLBI NIH HHS N01 HC095162 / NHLBI NIH HHS RC1 HL100543 / NHLBI NIH HHS K23 HL083091 / NHLBI NIH HHS N01HC95159 / NHLBI NIH HHS R01 HL103676 / NHLBI NIH HHS N01HC95163 / NHLBI NIH HHS N01 HC095166 / NHLBI NIH HHS N01 HC095163 / NHLBI NIH HHS R01 HL077612 / NHLBI NIH HHS R01 HL114626 / NHLBI NIH HHS N01HC95166 / NHLBI NIH HHS K23 HL130627 / NHLBI NIH HHS K24 HL103844 / NHLBI NIH HHS P30 ES005605 / NIEHS NIH HHS N01 HC095164 / NHLBI NIH HHS UL1 RR025005 / NCRR NIH HHS R01 HL093081 / NHLBI NIH HHS N01 HC095169 / NHLBI NIH HHS N01HC95160 / NHLBI NIH HHS R01 HL112986 / NHLBI NIH HHS P30 CA086862 / NCI NIH HHS N01 HC095159 / NHLBI NIH HHS UL1 TR000040 / NCATS NIH HHS N01 HC095161 / NHLBI NIH HHS N01HC95168 / NHLBI NIH HHS U01 DK048443 / NIDDK NIH HHS K24 HL131937 / NHLBI NIH HHS N01HC95165 / NHLBI NIH HHS N01 HC095167 / NHLBI NIH HHS N01HC95162 / NHLBI NIH HHS
- Language
- English
- Date published
- 11/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051575602771
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