Journal article
High clinical suspicion of donor-derived disease leads to timely recognition and early intervention to treat solid organ transplant-transmitted lymphocytic choriomeningitis virus
Transplant infectious disease, Vol.19(4), e12707
08/2017
DOI: 10.1111/tid.12707
PMID: 28423464
Abstract
Despite careful donor screening, unexpected donor‐derived infections continue to occur in organ transplant recipients (OTRs). Lymphocytic choriomeningitis virus (LCMV) is one such transplant‐transmitted infection that in previous reports has resulted in a high mortality among the affected OTRs. We report a LCMV case cluster that occurred 3 weeks post‐transplant in three OTRs who received allografts from a common organ donor in March 2013. Following confirmation of LCMV infection at Centers for Disease Control and Prevention, immunosuppression was promptly reduced and ribavirin and/or intravenous immunoglobulin therapy were initiated in OTRs. The liver recipient died, but right kidney recipients survived without significant sequelae and left kidney recipient survived acute LCMV infection with residual mental status deficit. Our series highlights how early recognition led to prompt therapeutic intervention, which may have contributed to more favorable outcome in the kidney transplant recipients.
Details
- Title: Subtitle
- High clinical suspicion of donor-derived disease leads to timely recognition and early intervention to treat solid organ transplant-transmitted lymphocytic choriomeningitis virus
- Creators
- Gagan Mathur - Department of Pathology; University of Iowa Carver College of Medicine; Iowa City IA USAKunal Yadav - Department of Internal Medicine-Infectious Diseases; University of Iowa Carver College of Medicine; Iowa City IA USABradley Ford - Department of Pathology; University of Iowa Carver College of Medicine; Iowa City IA USAIlana J Schafer - Viral Special Pathogens Branch; Centers for Disease Control and Prevention; Atlanta GA USASridhar V Basavaraju - Office of Blood, Organ, and Other Tissue Safety; Centers for Disease Control and Prevention; Atlanta GA USABarbara Knust - Viral Special Pathogens Branch; Centers for Disease Control and Prevention; Atlanta GA USAWun-Ju Shieh - Infectious Disease Pathology Branch; Centers for Disease Control and Prevention; Atlanta GA USASam Hill - Organ Donation Department; Iowa Donor Network; North Liberty IA USAGarret D Locke - Compliance & Quality Systems; Iowa Lions Eye Bank; Iowa City IA USAPatricia Quinlisk - State Health Department; Iowa Department of Public Health; Des Moines IA USAShelley Brown - Viral Special Pathogens Branch; Centers for Disease Control and Prevention; Atlanta GA USAArdith Gibbons - Viral Special Pathogens Branch; Centers for Disease Control and Prevention; Atlanta GA USADeborah Cannon - Viral Special Pathogens Branch; Centers for Disease Control and Prevention; Atlanta GA USAMatthew Kuehnert - Office of Blood, Organ, and Other Tissue Safety; Centers for Disease Control and Prevention; Atlanta GA USAStuart T Nichol - Viral Special Pathogens Branch; Centers for Disease Control and Prevention; Atlanta GA USAPierre E Rollin - Viral Special Pathogens Branch; Centers for Disease Control and Prevention; Atlanta GA USAUte Ströher - Viral Special Pathogens Branch; Centers for Disease Control and Prevention; Atlanta GA USARachel Miller - Department of Internal Medicine-Infectious Diseases; University of Iowa Carver College of Medicine; Iowa City IA USA
- Resource Type
- Journal article
- Publication Details
- Transplant infectious disease, Vol.19(4), e12707
- DOI
- 10.1111/tid.12707
- PMID
- 28423464
- ISSN
- 1398-2273
- eISSN
- 1399-3062
- Language
- English
- Date published
- 08/2017
- Academic Unit
- Epidemiology; Pathology
- Record Identifier
- 9984047886602771
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