Journal article
High-dimensional profiling of pediatric immune responses to solid organ transplantation
Cell reports. Medicine, Vol.4(8), pp.101147-101147
08/15/2023
DOI: 10.1016/j.xcrm.2023.101147
PMCID: PMC10439249
PMID: 37552988
Abstract
Solid organ transplant remains a life-saving therapy for children with end-stage heart, lung, liver, or kidney disease; however,-33% of allograft recipients experience acute rejection within the first year after trans-plant. Our ability to detect early rejection is hampered by an incomplete understanding of the immune changes associated with allograft health, particularly in the pediatric population. We performed detailed, multilineage, single-cell analysis of the peripheral blood immune composition in pediatric solid organ transplant recipients, with high-dimensional mass cytometry. Supervised and unsupervised analysis methods to study cell-type proportions indicate that the allograft type strongly influences the post-transplant immune profile. Further, when organ-specific differences are considered, graft health is associated with changes in the proportion of distinct T cell subpopulations. Together, these data form the basis for mechanistic studies into the pathobiology of rejection and allow for the development of new immunosuppressive agents with greater specificity.
Details
- Title: Subtitle
- High-dimensional profiling of pediatric immune responses to solid organ transplantation
- Creators
- Mahil Rao - Stanford UniversityMeelad Amouzgar - Stanford UniversityJames T. Harden - Stanford UniversityM. Gay Lapasaran - Stanford UniversityAmber Trickey - Stanford UniversityBrian Armstrong - RhoJonah Odim - National Institutes of HealthTracia Debnam - National Institutes of HealthCarlos O. Esquivel - Stanford UniversitySean C. Bendall - Stanford UniversityOlivia M. Martinez - Stanford UniversitySheri M. Krams - Stanford University
- Resource Type
- Journal article
- Publication Details
- Cell reports. Medicine, Vol.4(8), pp.101147-101147
- DOI
- 10.1016/j.xcrm.2023.101147
- PMID
- 37552988
- PMCID
- PMC10439249
- NLM abbreviation
- Cell Rep Med
- ISSN
- 2666-3791
- eISSN
- 2666-3791
- Publisher
- Elsevier
- Number of pages
- 19
- Grant note
- Stanford Transplant and Tissue Engineering Center of Excellence U01 AI1359590; T32 AI007290-37 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Stanford University Jackson Vaughan Critical Care Research Fund Stanford Maternal and Child Health Research Institute Stanford Immunology Training Grant
- Language
- English
- Date published
- 08/15/2023
- Academic Unit
- Critical Care; Stead Family Department of Pediatrics
- Record Identifier
- 9984775275902771
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