High-dose intravenous naloxone for the treatment of acute ischemic stroke

Charles P Olinger; Harold P Adams Jr; Thomas G Brott; Jose Biller; William G Barsan; Gilbert J Toffol; Robert W Eberle; John R Marler

doi:10.1161/01.STR.21.5.721

Back

High-dose intravenous naloxone for the treatment of acute ischemic stroke

Journal article

Open access

Peer reviewed

High-dose intravenous naloxone for the treatment of acute ischemic stroke

Charles P Olinger, Harold P Adams Jr, Thomas G Brott, Jose Biller, William G Barsan, Gilbert J Toffol, Robert W Eberle and John R Marler

Stroke (1970), Vol.21(5), pp.721-725

05/1990

DOI: 10.1161/01.STR.21.5.721

PMID: 2339451

Files and links (1)

url

https://doi.org/10.1161/01.STR.21.5.721View

Published (Version of record) Open Access

Abstract

To evaluate the safety and possible efficacy of high-dose naloxone for the treatment of acute cerebral ischemia, 38 patients received a loading dose of 160 mg/m2 over 15 minutes followed by a 24-hour infusion at the rate of 80 mg/m2/hr. Nausea and/or vomiting were common side effects. Naloxone was discontinued in seven patients (because of hypotension in one, bradycardia and hypotension in two, myoclonus in one, focal seizures in two, and hypertension in one); all seven patients responded to treatment and no permanent sequelae to naloxone were noted. Twelve of the 38 patients showed early neurologic improvement (by completion of the naloxone loading dose). However, there was no correlation between such a loading dose response and clinical outcome at 3 months. Our experience suggests that naloxone is safe at the dose used, but data for efficacy are inconclusive.

Details

Title: Subtitle: High-dose intravenous naloxone for the treatment of acute ischemic stroke
Creators: Charles P Olinger - Department of Neurology, University of Cincinnati, Ohio
Harold P Adams Jr - Department of Neurology, University of Cincinnati, Ohio
Thomas G Brott - Department of Neurology, University of Cincinnati, Ohio
Jose Biller - Department of Neurology, University of Cincinnati, Ohio
William G Barsan - Department of Neurology, University of Cincinnati, Ohio
Gilbert J Toffol - Department of Neurology, University of Cincinnati, Ohio
Robert W Eberle - Department of Neurology, University of Cincinnati, Ohio
John R Marler - Department of Neurology, University of Cincinnati, Ohio
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.21(5), pp.721-725
DOI: 10.1161/01.STR.21.5.721
PMID: 2339451
NLM abbreviation: Stroke
ISSN: 0039-2499
eISSN: 1524-4628
Language: English
Date published: 05/1990
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984020870102771

Metrics

14 Record Views

45 Times Cited - Web of Science