Journal article
High-dose tigecycline and colistin for successful treatment of disseminated carbapenem-resistant Klebsiella pneumoniae infection in a liver transplant recipient
BMJ case reports, Vol.2014(nov05 1), pp.bcr2014205865-bcr2014205865
2014
DOI: 10.1136/bcr-2014-205865
PMCID: PMC4225299
PMID: 25378111
Abstract
Solid organ transplantation (SOT) is a risk factor for the acquisition of carbapenem-resistant Klebsiella pneumoniae. This infection is associated with a high mortality rate given the limited armamentarium of antibiotics for multidrug-resistant organisms along with continued immunosuppression to prevent graft rejection. We report a case of carbapenem-resistant K. pneumoniae pneumonia, bacteraemia and intra-abdominal infection in a newly transplanted liver recipient. The patient was successfully treated with a long course of high-dose tigecycline and colistin, along with surgical drainage. We discuss SOT-relevant epidemiology, therapeutic options and the rationale for our treatment choice.
Details
- Title: Subtitle
- High-dose tigecycline and colistin for successful treatment of disseminated carbapenem-resistant Klebsiella pneumoniae infection in a liver transplant recipient
- Creators
- Jennifer Marie Dan - University of California, San DiegoMichel Henry Mendler - University of California, San DiegoAlan W Hemming - University of California, San DiegoSaima Aslam - University of California, San Diego
- Resource Type
- Journal article
- Publication Details
- BMJ case reports, Vol.2014(nov05 1), pp.bcr2014205865-bcr2014205865
- DOI
- 10.1136/bcr-2014-205865
- PMID
- 25378111
- PMCID
- PMC4225299
- ISSN
- 1757-790X
- eISSN
- 1757-790X
- Language
- English
- Date published
- 2014
- Academic Unit
- Surgery
- Record Identifier
- 9984322934502771
Metrics
51 Record Views