Journal article
High-dose vitamin C on sepsis: Protocol of a prospective, multi-centered, double-blinded, randomized, and placebo-controlled superiority study
Frontiers in medicine, Vol.9, pp.950246-950246
09/15/2022
DOI: 10.3389/fmed.2022.950246
PMCID: PMC9520308
PMID: 36186784
Abstract
Background: Sepsis is an inflammatory syndrome with life-threatening organ dysfunction and high mortality. In the recent 10 years, high-dose intravenous injection of vitamin C, the first-line antioxidant of humans, has received highlighted attention in the field of critical care. The study aims to examine the efficacy and safety of high-dose intravenous injection of vitamin C in the treatment of sepsis.
Methods and design: Here, we are conducting a prospective, multi-centered, double-blinded, randomized, and placebo-controlled superiority study named High-Dose Vitamin C on Sepsis (HDVCOS). A total of 620 participants diagnosed with sepsis in four participating sites across China that satisfy the eligibility criteria will be randomized at a ratio of 1:1 to receive treatment with a high-dose intravenous injection of vitamin C (200 mg/kg/24 h) or placebo (saline) for 4 days. The primary outcome is 28 days of mortality. The secondary outcomes include the incidence of organ failure, Sequential Organ Failure Assessment (SOFA) score change, organ support, the relationship between plasma vitamin C concentration and outcomes, and adverse events.
Conclusion: The findings of this study will provide potential evidence for high-dose intravenous injection of vitamin C in the treatment of sepsis.
Details
- Title: Subtitle
- High-dose vitamin C on sepsis: Protocol of a prospective, multi-centered, double-blinded, randomized, and placebo-controlled superiority study
- Creators
- Bing Zhao - Ruijin HospitalMengjiao Li - Shanghai Jiao Tong UniversityWenwu Sun - Ruijin HospitalJian Li - Ruijin HospitalLeshan Liu - Ruijin HospitalYihui Wang - Ruijin HospitalSilei Sun - Ruijin HospitalLili Xu - Ruijin HospitalXing Qi - , , , , , , , , , , , ,Mengqi Xie - Ruijin HospitalYuhua Zhou - Ruijin HospitalTongtian Ni - Ruijin HospitalYi Yao - Ruijin HospitalPeili Chen - Ruijin HospitalMeiling Yu - Ruijin HospitalWeisong Jiang - Ruijin HospitalNing Ning - Ruijin HospitalHuiqiu Sheng - Ruijin HospitalErzhen Chen - Shanghai Jiao Tong UniversityRuilan Wang - Shanghai First People's HospitalChaoyang Tong - The First Affiliated Hospital, Sun Yat-sen UniversityYu Cao - Sichuan UniversityMingwei Sun - Fourth People's Hospital of Sichuan ProvinceEnqiang Mao - Ruijin Hospital
- Resource Type
- Journal article
- Publication Details
- Frontiers in medicine, Vol.9, pp.950246-950246
- Publisher
- Frontiers Media S.A
- DOI
- 10.3389/fmed.2022.950246
- PMID
- 36186784
- PMCID
- PMC9520308
- ISSN
- 2296-858X
- eISSN
- 2296-858X
- Language
- English
- Date published
- 09/15/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984696656802771
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