High-quality life extension by the enzyme peptide methionine sulfoxide reductase

Hongyu Ruan; Xiang Dong Tang; Mai-Lei Chen; Me-Ling A Joiner; Guangrong Sun; Nathan Brot; Herbert Weissbach; Stephen H Heinemann; Linda Iverson; Chun-Fang Wu; Toshinori Hoshi

doi:10.1073/pnas.032671199

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High-quality life extension by the enzyme peptide methionine sulfoxide reductase

Journal article

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High-quality life extension by the enzyme peptide methionine sulfoxide reductase

Hongyu Ruan, Xiang Dong Tang, Mai-Lei Chen, Me-Ling A Joiner, Guangrong Sun, Nathan Brot, Herbert Weissbach, Stephen H Heinemann, Linda Iverson, Chun-Fang Wu, …

Proceedings of the National Academy of Sciences - PNAS, Vol.99(5), pp.2748-2753

03/05/2002

DOI: 10.1073/pnas.032671199

PMCID: PMC122419

PMID: 11867705

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Abstract

Cumulative oxidative damages to cell constituents are considered to contribute to aging and age-related diseases. The enzyme peptide methionine sulfoxide reductase A (MSRA) catalyzes the repair of oxidized methionine in proteins by reducing methionine sulfoxide back to methionine. However, whether MSRA plays a role in the aging process is poorly understood. Here we report that overexpression of the msrA gene predominantly in the nervous system markedly extends the lifespan of the fruit fly Drosophila . The MSRA transgenic animals are more resistant to paraquat-induced oxidative stress, and the onset of senescence-induced decline in the general activity level and reproductive capacity is delayed markedly. The results suggest that oxidative damage is an important determinant of lifespan, and MSRA may be important in increasing the lifespan in other organisms including humans.

Biological Sciences

Details

Title: Subtitle: High-quality life extension by the enzyme peptide methionine sulfoxide reductase
Creators: Hongyu Ruan - Department of Biological Sciences, University of Iowa, Iowa City, IA 52242
Xiang Dong Tang - Department of Biological Sciences, University of Iowa, Iowa City, IA 52242
Mai-Lei Chen - Department of Biological Sciences, University of Iowa, Iowa City, IA 52242
Me-Ling A Joiner - Department of Biological Sciences, University of Iowa, Iowa City, IA 52242
Guangrong Sun - Department of Biological Sciences, University of Iowa, Iowa City, IA 52242
Nathan Brot - Department of Biological Sciences, University of Iowa, Iowa City, IA 52242
Herbert Weissbach - Department of Biological Sciences, University of Iowa, Iowa City, IA 52242
Stephen H Heinemann - Department of Biological Sciences, University of Iowa, Iowa City, IA 52242
Linda Iverson - Department of Biological Sciences, University of Iowa, Iowa City, IA 52242
Chun-Fang Wu - Department of Biological Sciences, University of Iowa, Iowa City, IA 52242
Toshinori Hoshi - Department of Biological Sciences, University of Iowa, Iowa City, IA 52242
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.99(5), pp.2748-2753
DOI: 10.1073/pnas.032671199
PMID: 11867705
PMCID: PMC122419
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 03/05/2002
Academic Unit: Iowa Neuroscience Institute; Biology
Record Identifier: 9984070293202771

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