Journal article
High-resolution whole-brain DCE-MRI using constrained reconstruction: Prospective clinical evaluation in brain tumor patients
Medical physics (Lancaster), Vol.43(5), pp.2013-2023
05/2016
DOI: 10.1118/1.4944736
PMCID: PMC4826379
PMID: 27147313
Abstract
Purpose:
To clinically evaluate a highly accelerated T1-weighted dynamic contrast-enhanced (DCE) MRI technique that provides high spatial resolution and whole-brain coverage via undersampling and constrained reconstruction with multiple sparsity constraints.
Methods:
Conventional (rate-2 SENSE) and experimental DCE-MRI (rate-30) scans were performed 20 minutes apart in 15 brain tumor patients. The conventional clinical DCE-MRI had voxel dimensions 0.9 × 1.3 × 7.0 mm3, FOV 22 × 22 × 4.2 cm3, and the experimental DCE-MRI had voxel dimensions 0.9 × 0.9 × 1.9 mm3, and broader coverage 22 × 22 × 19 cm3. Temporal resolution was 5 s for both protocols. Time-resolved images and blood–brain barrier permeability maps were qualitatively evaluated by two radiologists.
Results:
The experimental DCE-MRI scans showed no loss of qualitative information in any of the cases, while achieving substantially higher spatial resolution and whole-brain spatial coverage. Average qualitative scores (from 0 to 3) were 2.1 for the experimental scans and 1.1 for the conventional clinical scans.
Conclusions:
The proposed DCE-MRI approach provides clinically superior image quality with higher spatial resolution and coverage than currently available approaches. These advantages may allow comprehensive permeability mapping in the brain, which is especially valuable in the setting of large lesions or multiple lesions spread throughout the brain.
Details
- Title: Subtitle
- High-resolution whole-brain DCE-MRI using constrained reconstruction: Prospective clinical evaluation in brain tumor patients
- Creators
- Yi Guo - University of Southern CaliforniaR. Marc Lebel - GE HealthcareYinghua Zhu - University of Southern CaliforniaSajan Goud Lingala - University of Southern CaliforniaMark S Shiroishi - University of Southern CaliforniaMeng Law - University of Southern CaliforniaKrishna Nayak - University of Southern California
- Resource Type
- Journal article
- Publication Details
- Medical physics (Lancaster), Vol.43(5), pp.2013-2023
- DOI
- 10.1118/1.4944736
- PMID
- 27147313
- PMCID
- PMC4826379
- NLM abbreviation
- Med Phys
- ISSN
- 0094-2405
- eISSN
- 2473-4209
- Number of pages
- 11
- Grant note
- KL2TR000131 / Southern California Clinical and Translational Science Institute (SC CTSI) (http://dx.doi.org/10.13039/100009410) UL1TR000130 / National Center for Advancing Translational Sciences (NCATS) (http://dx.doi.org/10.13039/100006108)
- Language
- English
- Date published
- 05/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology
- Record Identifier
- 9984197006702771
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