Journal article
High risk of spontaneous preterm birth among infants with gastroschisis
American journal of medical genetics. Part A, Vol.179(1), pp.37-42
01/2019
DOI: 10.1002/ajmg.a.60675
PMID: 30549407
Abstract
We examined the association between gastroschisis and preterm birth (PTB, <37 weeks) by subtype. The sample was drawn from singleton live births in California from 2007 to 2012 contained in a birth cohort file maintained by the California Office of Statewide Health Planning and Development (n = 2,891,965; 1,421 with gastroschisis). Relative risks (RRs) and 95% confidence intervals (CIs) were calculated for PTB by gestational age (<34, 34-36, and any <37 weeks) and by type (spontaneous labor with intact membranes, preterm premature rupture of the membranes [PPROM], provider initiated) and were adjusted for maternal characteristics. Over 44.5% of infants with gastroschisis were born preterm because of spontaneous etiologies; notably, 8.4% of infants with gastroschisis were born <34 weeks because of spontaneous etiologies (adjusted RRs 9.1-12.2). Overall, 53.7% of infants with gastroschisis were born preterm compared with only 6.9% of infants without gastroschisis (adjusted RR 15.2, 95% CI 13.6-19.5) and are at particularly high risk of spontaneous PTB. Nearly 9% of infants with gastroschisis delivered <34 weeks, regardless of preterm etiology, indicating that these infants are at great risk for PTB morbidities in addition to the complications from gastroschisis.
Details
- Title: Subtitle
- High risk of spontaneous preterm birth among infants with gastroschisis
- Creators
- Rebecca J Baer - California Preterm Birth Initiative, University of California San Francisco, San Francisco, CaliforniaChristina D Chambers - Department of Pediatrics, University of California San Diego, La Jolla, CaliforniaKelli K Ryckman - Departments of Epidemiology and Pediatrics, University of Iowa, Iowa City, IowaScott P Oltman - Department of Epi and Biostats, University of California San Francisco, San Francisco, CaliforniaLarry Rand - Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CaliforniaLaura L Jelliffe-Pawlowski - Department of Epi and Biostats, University of California San Francisco, San Francisco, California
- Resource Type
- Journal article
- Publication Details
- American journal of medical genetics. Part A, Vol.179(1), pp.37-42
- Publisher
- United States
- DOI
- 10.1002/ajmg.a.60675
- PMID
- 30549407
- ISSN
- 1552-4833
- eISSN
- 1552-4833
- Grant note
- California Preterm Birth Initiative
- Language
- English
- Date published
- 01/2019
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology
- Record Identifier
- 9983996199602771
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