High-sodium diet does not worsen endothelial function in female patients with postural tachycardia syndrome

Emily C Smith; Jorge Celedonio; Victor C Nwazue; Emily M Garland; Sachin Y Paranjape; Abby H Chopoorian; Amr Wahba; Italo Biaggioni; Bonnie Black; Cyndya A Shibao; André Diedrich; Luis E Okamoto; Satish R Raj; Alfredo Gamboa

doi:10.1007/s10286-021-00772-y

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High-sodium diet does not worsen endothelial function in female patients with postural tachycardia syndrome

Journal article

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High-sodium diet does not worsen endothelial function in female patients with postural tachycardia syndrome

Emily C Smith, Jorge Celedonio, Victor C Nwazue, Emily M Garland, Sachin Y Paranjape, Abby H Chopoorian, Amr Wahba, Italo Biaggioni, Bonnie Black, Cyndya A Shibao, …

Clinical autonomic research, Vol.31(4), pp.563-571

08/01/2021

DOI: 10.1007/s10286-021-00772-y

PMCID: PMC8295180

PMID: 33689063

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https://www.ncbi.nlm.nih.gov/pmc/articles/8295180View

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Abstract

Postural tachycardia syndrome (POTS), a syndrome characterized by orthostatic symptoms and a heart rate increase of at least 30 beats per minute in the absence of hypotension upon standing, is often accompanied by increased sympathetic activity and low blood volume. A common non-pharmacologic recommendation for patients with POTS is a high-sodium (HS) diet with the goal of bolstering circulating blood volume. The objective of this study is to assess the effects of 6 days of a HS diet on endothelial function in POTS. A total of 14 patients with POTS and 13 age-matched healthy controls, all females, were studied following 6 days on a low-sodium (LS) diet (10 mEq/day) and 6 days on a HS diet (300 mEq/day) in a crossover design. We measured endothelial function following reactive hyperemia in the brachial artery using flow-mediated dilation (FMD), leg blood flow (LBF) using strain gauge plethysmography in the calf, and reactive hyperemic index (RHI) in the microcirculation of the hand using pulsatile arterial tonometry. On the LS diet, FMD% did not differ between patients with POTS and the healthy controls although peak brachial artery diameter was lower for the patient group. RHI was higher for the patient group than for the controls, but there were no differences in post-ischemic LBF increase. On the HS diet, there were no between-group differences in FMD%, LBF increase, or RHI. In summary, a HS diet for 6 days did not induce endothelial dysfunction. This non-pharmacologic treatment used for patients with POTS does not negatively affect endothelial function when used for a sub-acute duration. ClinicalTrials.gov NCT01550315; March 9, 2012.

Blood Pressure

Cross-Over Studies

Diet

Female

Heart Rate

Humans

Postural Orthostatic Tachycardia Syndrome

Sodium

Details

Title: Subtitle: High-sodium diet does not worsen endothelial function in female patients with postural tachycardia syndrome
Creators: Emily C Smith - Vanderbilt University Medical Center
Jorge Celedonio - Vanderbilt University Medical Center
Victor C Nwazue - Vanderbilt University Medical Center
Emily M Garland - Vanderbilt University Medical Center
Sachin Y Paranjape - Vanderbilt University Medical Center
Abby H Chopoorian - Vanderbilt University
Amr Wahba - Vanderbilt University Medical Center
Italo Biaggioni - Vanderbilt University Medical Center
Bonnie Black - Vanderbilt University Medical Center
Cyndya A Shibao - Vanderbilt University Medical Center
André Diedrich - Vanderbilt University Medical Center
Luis E Okamoto - Vanderbilt University Medical Center
Satish R Raj - Vanderbilt University Medical Center
Alfredo Gamboa - Vanderbilt University Medical Center
Resource Type: Journal article
Publication Details: Clinical autonomic research, Vol.31(4), pp.563-571
DOI: 10.1007/s10286-021-00772-y
PMID: 33689063
PMCID: PMC8295180
NLM abbreviation: Clin Auton Res
ISSN: 0959-9851
eISSN: 1619-1560
Grant note: R01 HL149386 / NHLBI NIH HHS P01 HL056693 / NHLBI NIH HHS UL1 TR000445 / NCATS NIH HHS R01 HL102387 / NHLBI NIH HHS
Language: English
Date published: 08/01/2021
Academic Unit: Internal Medicine
Record Identifier: 9984702941502771

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