Journal article
High-speed automated discrete blood sampling for positron emission tomography
The Journal of nuclear medicine (1978), Vol.34(8), pp.1357-1360
08/1993
PMID: 8326399
Abstract
A computer controlled blood sampling system was designed specifically for rapid blood sampling for quantitative PET studies and uses solenoids that pinch silastic tubing, a roller pump and an inexpensive fraction collector. The controlling computer is an Apple II plus. The maximum sampling rate is one sample per 2 sec. Typical sample size is 0.90 +/- 0.02 g s.d. The loss of blood per sample is 2.6 ml. Tubing dead space is 1.2 ml. The response to a step change in activity between samples is 91% of the expected activity during high-speed sampling and 99% in the slower sampling mode. The major advantage of this device over flow-through detectors is that the blood is available for further processing to measure plasma or metabolite activities. This device has become a useful tool for quantitative PET studies, resulting in reliable sampling, lower radiation dose to personnel and fewer personnel necessary to conduct a study.
Details
- Title: Subtitle
- High-speed automated discrete blood sampling for positron emission tomography
- Creators
- M M Graham - Department of Radiology, University of Washington, Seattle 98195B L Lewellen
- Resource Type
- Journal article
- Publication Details
- The Journal of nuclear medicine (1978), Vol.34(8), pp.1357-1360
- Publisher
- United States
- PMID
- 8326399
- ISSN
- 0161-5505
- eISSN
- 1535-5667
- Grant note
- CA42045 / NCI NIH HHS
- Language
- English
- Date published
- 08/1993
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984047653002771
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