Journal article
High-speed bubble-segmented blood sampler for the rat
Journal of applied physiology: respiratory, environmental and exercise physiology, Vol.57(4), pp.1284-1287
1984
DOI: 10.1152/jappl.1984.57.4.1284
PMID: 6501037
Abstract
An arterial blood sampler for use in the conscious rat is described. With this apparatus it is possible to obtain small (10 microliter) whole-blood or plasma samples as frequently as 1/s and to derive accurate arterial time-concentration curves in the first 60-120 s after compounds are injected for regional blood flow or pharmacokinetic measurements. The blood is withdrawn from an implanted arterial catheter into polyethylene tubing at a constant rate while bubbles are introduced at regular intervals via a side channel into the column of blood. Although some dispersion of blood samples occurs as the tubing is traversed, this can be mathematically corrected. However, correction is unnecessary if the information of interest is the area under the time-concentration curve.
Details
- Title: Subtitle
- High-speed bubble-segmented blood sampler for the rat
- Creators
- M. M GRAHAM - Univ. Washington, nuclear medicine, Seattle WA 98195, United StatesG. L ABBOTT - Univ. Washington, nuclear medicine, Seattle WA 98195, United States
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology: respiratory, environmental and exercise physiology, Vol.57(4), pp.1284-1287
- Publisher
- American Physiological Society; Bethesda, MD
- DOI
- 10.1152/jappl.1984.57.4.1284
- PMID
- 6501037
- ISSN
- 0161-7567
- eISSN
- 2691-2465
- Language
- English
- Date published
- 1984
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984047859902771
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