High success rates of sedation-free brain MRI scanning in young children using simple subject preparation protocols with and without a commercial mock scanner–the Diabetes Research in Children Network (DirecNet) experience

Naama Barnea-Goraly; Stuart A Weinzimer; Katrina J Ruedy; Nelly Mauras; Roy W Beck; Matt J Marzelli; Paul K Mazaika; Tandy Aye; Neil H White; Eva Tsalikian; Larry Fox; Craig Kollman; Peiyao Cheng; Allan L Reiss; Diabetes Research in Children Network (DirecNet)

doi:10.1007/s00247-013-2798-7

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High success rates of sedation-free brain MRI scanning in young children using simple subject preparation protocols with and without a commercial mock scanner–the Diabetes Research in Children Network (DirecNet) experience

Journal article

Peer reviewed

High success rates of sedation-free brain MRI scanning in young children using simple subject preparation protocols with and without a commercial mock scanner–the Diabetes Research in Children Network (DirecNet) experience

Naama Barnea-Goraly, Stuart A Weinzimer, Katrina J Ruedy, Nelly Mauras, Roy W Beck, Matt J Marzelli, Paul K Mazaika, Tandy Aye, Neil H White, Eva Tsalikian, …

Pediatric radiology, Vol.44(2), pp.181-186

02/2014

DOI: 10.1007/s00247-013-2798-7

PMCID: PMC3946760

PMID: 24096802

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https://www.ncbi.nlm.nih.gov/pmc/articles/3946760View

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Abstract

Background The ability to lie still in an MRI scanner is essential for obtaining usable image data. To reduce motion, young children are often sedated, adding significant cost and risk. Objective We assessed the feasibility of using a simple and affordable behavioral desensitization program to yield high-quality brain MRI scans in sedation-free children. Materials and methods 222 children (4–9.9 years), 147 with type 1 diabetes and 75 age-matched non-diabetic controls, participated in a multi-site study focused on effects of type 1 diabetes on the developing brain. T1-weighted and diffusion-weighted imaging (DWI) MRI scans were performed. All children underwent behavioral training and practice MRI sessions using either a commercial MRI simulator or an inexpensive mock scanner consisting of a toy tunnel, vibrating mat, and video player to simulate the sounds and feel of the MRI scanner. Results 205 children (92.3%), mean age 7 ± 1.7 years had high-quality T1-W scans and 174 (78.4%) had high-quality diffusion-weighted scans after the first scan session. With a second scan session, success rates were 100% and 92.5% for T1-and diffusion-weighted scans, respectively. Success rates did not differ between children with type 1 diabetes and children without diabetes, or between centers using a commercial MRI scan simulator and those using the inexpensive mock scanner. Conclusion Behavioral training can lead to a high success rate for obtaining high-quality T1-and diffusion-weighted brain images from a young population without sedation.

Diabetes

Diffusion-weighted imaging

MRI

Behavioral preparation

Sedation

Children

Sedation-free

Mock scanner

Details

Title: Subtitle: High success rates of sedation-free brain MRI scanning in young children using simple subject preparation protocols with and without a commercial mock scanner–the Diabetes Research in Children Network (DirecNet) experience
Creators: Naama Barnea-Goraly - Department of Psychiatry and Behavioral Sciences, Center for Interdisciplinary Brain Sciences Research, Stanford, CA, USA
Stuart A Weinzimer - Pediatric Endocrinology, Yale University, New Haven, CT, USA
Katrina J Ruedy - Jaeb Center for Health Research, 15310 Amberly Drive, Ste. 350, Tampa, FL 33647, USA
Nelly Mauras - Pediatric Endocrinology, Nemours Children’s Clinic, Jacksonville, FL, USA
Roy W Beck - Jaeb Center for Health Research, 15310 Amberly Drive, Ste. 350, Tampa, FL 33647, USA
Matt J Marzelli - Department of Psychiatry and Behavioral Sciences, Center for Interdisciplinary Brain Sciences Research, Stanford, CA, USA
Paul K Mazaika - Department of Psychiatry and Behavioral Sciences, Center for Interdisciplinary Brain Sciences Research, Stanford, CA, USA
Tandy Aye - Department of Pediatrics, Stanford University, Stanford, CA, USA
Neil H White - Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA
Eva Tsalikian - Pediatric Endocrinology, University of Iowa, Iowa City, IA, USA
Larry Fox - Pediatric Endocrinology, Nemours Children’s Clinic, Jacksonville, FL, USA
Craig Kollman - Jaeb Center for Health Research, 15310 Amberly Drive, Ste. 350, Tampa, FL 33647, USA
Peiyao Cheng - Jaeb Center for Health Research, 15310 Amberly Drive, Ste. 350, Tampa, FL 33647, USA
Allan L Reiss - Department of Psychiatry and Behavioral Sciences, Center for Interdisciplinary Brain Sciences Research, Stanford, CA, USA
Diabetes Research in Children Network (DirecNet)
Resource Type: Journal article
Publication Details: Pediatric radiology, Vol.44(2), pp.181-186
DOI: 10.1007/s00247-013-2798-7
PMID: 24096802
PMCID: PMC3946760
NLM abbreviation: Pediatr Radiol
ISSN: 0301-0449
eISSN: 1432-1998
Language: English
Date published: 02/2014
Academic Unit: Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984093360302771

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