Journal article
High trans but not saturated fat beverage causes an acute reduction in postprandial vascular endothelial function but not arterial stiffness in humans
Vascular medicine (London, England), Vol.21(5), pp.429-436
10/2016
DOI: 10.1177/1358863X16656063
PMCID: PMC6235444
PMID: 27558396
Abstract
A diet high in trans-fatty acids (TFAs) is associated with a higher risk of cardiovascular disease (CVD) than a diet high in saturated fatty acids (SFAs), but the mechanisms remain unclear. We hypothesized that a beverage high in TFAs would cause a larger reduction in postprandial endothelial function and an increase in arterial stiffness, in part from greater reductions in insulin sensitivity, compared with a beverage high in SFAs. Eleven healthy adults (aged 47±5 years) ingested a warm test beverage (520 kcal, 56 g total fat, 5 g carbohydrate, 1 g protein) high in either TFAs or SFAs in a randomized cross-over study. Ingestion of the beverage high in TFAs (p<0.01) but not high in SFAs (p=0.49) decreased endothelial function (brachial artery flow-mediated dilation, mmΔ) at 3-4 hours (p<0.01 for time; p=0.034 for interaction), but did not alter aortic stiffness or carotid β-stiffness. The homeostasis model of insulin resistance (interaction p=0.062) tended to decrease after SFAs but not TFAs. A beverage high in TFAs but not SFAs results in a postprandial reduction in endothelial function and a trend for decreased insulin sensitivity, potentially explaining the higher risk of CVD with a diet high in TFAs.
Details
- Title: Subtitle
- High trans but not saturated fat beverage causes an acute reduction in postprandial vascular endothelial function but not arterial stiffness in humans
- Creators
- Abbi D Lane-Cordova - Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USAJordan R Witmer - Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USAKaitlyn Dubishar - Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USALyndsey E DuBose - Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USACatherine A Chenard - Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USAKyle J Siefers - Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USAJanie E Myers - Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USALauren J Points - Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USAGary L Pierce - Abboud Cardiovascular Research Center, The University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Vascular medicine (London, England), Vol.21(5), pp.429-436
- Publisher
- England
- DOI
- 10.1177/1358863X16656063
- PMID
- 27558396
- PMCID
- PMC6235444
- ISSN
- 1358-863X
- eISSN
- 1477-0377
- Grant note
- T32 HL007121 / NHLBI NIH HHS T32 HL007638 / NHLBI NIH HHS U54 TR001356 / NCATS NIH HHS
- Language
- English
- Date published
- 10/2016
- Academic Unit
- Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984002596202771
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