Journal article
Higher Antigen Content Improves the Immune Response to 2009 H1N1 Influenza Vaccine in HIV-Infected Adults: A Randomized Clinical Trial
The Journal of infectious diseases, Vol.205(5), pp.703-712
Editor's Choice
03/01/2012
DOI: 10.1093/infdis/jir837
PMCID: PMC3274370
PMID: 22275399
Abstract
(See the editorial commentary by Overton, on pages
697–9
.)
Background.
The immunogenicity of a high hemagglutinin (HA) dose or a second dose of influenza vaccine in human immunodeficiency virus (HIV)–infected individuals has not been fully explored.
Methods.
One hundered ninety-two HIV-infected individuals aged 18–64 years were stratified by CD4 cell count (<200 cells/mL or ≥200 cells/mL) and randomized to receive 2 doses of 15 μg or 30 μg HA 2009 H1N1 vaccine 21 days apart. Hemagglutination inhibition (HAI) and microneutralization (MN) antibodies were measured on days 0, 10, 21, 31, 42, and 201.
Results.
Recipients of 30 μg HA had significantly higher HAI geometric mean titers (GMTs), compared with recipients of 15 μg HA on days 10 (139.0 vs 51.9;
P
= .01), 21 (106.7 vs 51.9;
P
= .001), and 31 (130.0 vs 73.7;
P
= .03) but not on days 42 (91.8 vs 61.6;
P
= .11) and 201 (43.0 vs 27.0;
P
= .08). When analyzed by CD4 cell count stratum, HAI GMTs were significantly higher among 30 μg HA recipients than among 15 μg HA in the CD4 cell count <200 cells/mL stratum on days 21 and 31 and the MN GMTs on days 10, 21, 31, and 42 (
P
< .05). In the CD4 cell count ≥200 cells/mL stratum, MN GMTs were significantly higher among recipients of 30 μg HA than among recipients of 15 μg HA on day 10 (
P
= .03).
Conclusion.
Increasing the HA dose of the 2009 H1N1 vaccine improves the vaccine’s immunogenicity in HIV-infected individuals.
Clinical Trials Registration.
NCT00992433.
Details
- Title: Subtitle
- Higher Antigen Content Improves the Immune Response to 2009 H1N1 Influenza Vaccine in HIV-Infected Adults: A Randomized Clinical Trial
- Creators
- Hana M El Sahly - Department of Molecular Virology and MicrobiologyCharles Davis - University of Maryland, BaltimoreKaren Kotloff - University of Maryland, BaltimoreJeffery Meier - Department of Internal Medicine, University of Iowa Carver College of Medicine and Iowa City Veterans Affairs Medical Center, Iowa CityPatricia L Winokur - Department of Internal Medicine, University of Iowa Carver College of Medicine and Iowa City Veterans Affairs Medical Center, Iowa CityAnna Wald - Department of Medicine, University of Washington, SeattleChristine Johnston - Department of Medicine, University of Washington, SeattleSarah L George - Department of Internal Medicine, Division of Infectious Diseases, Saint Louis UniversityRebecca C Brady - Division of Infectious DiseasesCorinne Lehmann - Division of Adolescent Medicine, Cincinnati Children’s Hospital Medical Center, OhioAbbie Stokes-Riner - The EMMES Corporation, Rockville, MarylandWendy A Keitel - Department of Molecular Virology and Microbiology
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.205(5), pp.703-712
- Publisher
- Oxford University Press
- Series
- Editor's Choice
- DOI
- 10.1093/infdis/jir837
- PMID
- 22275399
- PMCID
- PMC3274370
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 03/01/2012
- Academic Unit
- Infectious Diseases; Epidemiology; Medicine Administration; Internal Medicine
- Record Identifier
- 9984094576702771
Metrics
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