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Higher Muscle Damage Triggered by Shorter Inter-Set Rest Periods in Volume-Equated Resistance Exercise
Journal article   Open access   Peer reviewed

Higher Muscle Damage Triggered by Shorter Inter-Set Rest Periods in Volume-Equated Resistance Exercise

Gilmar Weber Senna, Estelio Henrique Martin Dantas, Estevao Scudese, Paula Paraguassu Brandao, Vitor A. Lira, Matheus Baffi, Luiz Claudio Pereira Ribeiro, Roberto Simao, Ewan Thomas and Antonino Bianco
Frontiers in physiology, Vol.13, pp.827847-827847
02/28/2022
DOI: 10.3389/fphys.2022.827847
PMCID: PMC8920480
PMID: 35295573
url
https://doi.org/10.3389/fphys.2022.827847View
Published (Version of record) Open Access

Abstract

ObjectivesThe aim of the manuscript was to analyze the effects of two rest periods between volume-equated resistance exercise (RE) on inflammatory responses (cytokines and leukocyte) and muscle damage. MethodsTen trained men (26.40 +/- 4.73 years, 80.71 +/- 8.95 kg, and 176.03 +/- 6.11 cm) voluntarily participated in training sessions consisting of five sets of 10 reps performed at 10-RM on (1) the barbell bench press followed by (2) leg press, with either 1- or 3-min rest between sets and exercises. Circulating concentrations of different biomarkers was measured before (Pre), and after 3 h (excepted for cytokines), 6, 12, and 24 h from exercise. The rate of perceived exertion (RPE) was recorded after each set on both planned visits. ResultsWe found greater increases triggered by the 1-min rest period in Creatine Kinase (CK), occurring from 12 to 24 h post-exercise compared to the 3-min rest condition. A significant increase in the 1-min rest condition was also observed in the total number of leukocytes, neutrophils, and monocytes. The 1-min rest period also triggered increases compared to baseline in pro-inflammatory cytokines [Interleukin 1 beta (IL-1 beta), p = 0.004; tumor necrosis factor alpha (TNF-alpha), p = 0.01; and granulocyte-macrophage colony-stimulating factor (GM-CSF), p = 0.01], which were more evident after 6 and 12 h post-exercise. Similarly, increases in anti-inflammatory cytokines [Interleukin 5 (IL-5), p = 0.01; Interleukin 6 (IL-6), p = 0.01; and Interleukin 10 (IL-10), p = 0.01] at all time-points were observed. ConclusionOur results indicate that a 1-min rest condition in volume-equated RE promoted greater overall muscle tissue damage with a longer duration of the inflammatory processes compared to a 3-min rest.
Life Sciences & Biomedicine Physiology Science & Technology

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