Journal article
Higher Risks of Toxicity and Incomplete Recovery in 13- to 17-Year-Old Females after Marrow Donation: RDSafe Peds Results
Biology of blood and marrow transplantation, Vol.25(5), pp.955-964
05/2019
DOI: 10.1016/j.bbmt.2018.12.765
PMCID: PMC6511296
PMID: 30605731
Abstract
•Children commonly report pain (71%) and symptoms (59%) at 24 to 48 hours after bone marrow (BM) donation.•Older age and female sex are associated with higher levels of pain peri-BM donation.•Females age 13 to 17 years are at increased risk for grade 2 to 4 pain at 1 year after BM donation.•More than 20% of donors age 13 to 17 do not return to baseline pain level at 1 year after BM donation.
Although donation of bone marrow (BM) or peripheral blood stem cells (PBSCs) from children to family members undergoing allogeneic transplantation are well-established procedures, studies detailing levels of pain, symptoms, and long-term recovery are lacking. To address this lack, we prospectively enrolled 294 donors age <18 years at 25 pediatric transplantation centers in North America, assessing them predonation, peridonation, and at 1 month, 6 months, and 1 year postdonation. We noted that 71% of children reported pain and 59% reported other symptoms peridonation, with resolution to 14% and 12% at 1 month postdonation. Both older age (age 13 to 17 years versus younger) and female sex were associated with higher levels of pain peridonation, with the highest rates in older females (57% with grade 2-4 pain and 17% with grade 3-4 pain). Multivariate analyses showed a 4-fold increase in risk for older females compared with males age <13 years (P <.001). At 1 year, 11% of 13- to 17-year-old females reported grade 2-4 pain, compared with 3% of males age 13 to 17 years, 0% of females age <13 years, and 1% of males age <13 years (P = .01). Males and females age 13 to 17 years failed to return to predonation pain levels at 1 year 22% and 23% of the time, respectively, compared with 3% and 10% in males and females age <13 years (P = .002). Our data show that females age 13 to 17 years are at increased risk of grade 2-4 pain at 1 year and >20% of females and males age 13 to 17 years do not return to baseline pain levels by 1 year after BM donation. Studies aimed at decreasing symptoms and improving recovery in older children are warranted.
Details
- Title: Subtitle
- Higher Risks of Toxicity and Incomplete Recovery in 13- to 17-Year-Old Females after Marrow Donation: RDSafe Peds Results
- Creators
- Michael A. Pulsipher - Children's Hospital of Los AngelesBrent R. Logan - Medical College of WisconsinDeidre M. Kiefer - Center for International Blood and Marrow Transplant ResearchPintip Chitphakdithai - Center for International Blood and Marrow Transplant ResearchMarcie L. Riches - University of North Carolina HospitalsJ. Douglas Rizzo - Medical College of WisconsinPaolo Anderlini - The University of Texas MD Anderson Cancer CenterSusan F. Leitman - National Institutes of Health Clinical CenterJames W. Varni - Department of Landscape Architecture & Urban Planning, Center for Health Systems & Design, Texas A&M University, College Station, TexasHati Kobusingye - Center for International Blood and Marrow Transplant ResearchRaeAnne M. Besser - Center for International Blood and Marrow Transplant ResearchJohn P. Miller - National Marrow Donor ProgramRebecca J. Drexler - Center for International Blood and Marrow Transplant ResearchAly Abdel-Mageed - Helen DeVos Children's HospitalIbrahim A. Ahmed - Children's Mercy HospitalEdward D. Ball - University of California San Diego Medical CenterBrian J. Bolwell - Cleveland ClinicNancy J. Bunin - Children's Hospital of PhiladelphiaAlexandra Cheerva - Kosair Children's HospitalDavid C. Delgado - Riley Hospital for ChildrenChristopher C. Dvorak - UCSF Benioff Children's HospitalAlfred P. Gillio - Hackensack Meridian HealthTheresa E. Hahn - Roswell Park Cancer InstituteGregory A. Hale - Johns Hopkins All Children's HospitalAnn E. Haight - Children's Healthcare of AtlantaBrandon M. Hayes-Lattin - Doernbecher Children's HospitalKimberly A. Kasow - Pediatric Hematology Oncology Program, Bone Marrow and Stem Cell Transplantation Program, University of North Carolina Healthcare, Chapel Hill, North CarolinaMichael Linenberger - Fred Hutch Cancer CenterMargarida Magalhaes-Silverman - University of IowaShahram Mori - Florida Hospital Cancer InstituteVinod K. Prasad - Duke Medical CenterTroy C. Quigg - CHRISTUS Transplant InstituteIndira Sahdev - Cohen Children's Medical CenterJeffrey R. Schriber - HonorHealthShalini Shenoy - St. Louis Children's HospitalWilliam T. Tse - Lurie Children's HospitalGregory A. Yanik - University of MichiganWillis H. Navarro - Center for International Blood and Marrow Transplant ResearchMary M. Horowitz - Medical College of WisconsinDennis L. Confer - National Marrow Donor ProgramBronwen E. Shaw - Medical College of WisconsinGalen E. Switzer - University of Pittsburgh
- Resource Type
- Journal article
- Publication Details
- Biology of blood and marrow transplantation, Vol.25(5), pp.955-964
- DOI
- 10.1016/j.bbmt.2018.12.765
- PMID
- 30605731
- PMCID
- PMC6511296
- NLM abbreviation
- Biol Blood Marrow Transplant
- ISSN
- 1083-8791
- eISSN
- 1523-6536
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute; DOI: 10.13039/100000060, name: National Institute of Allergy and Infectious Diseases; DOI: 10.13039/100000006, name: Office of Naval Research
- Language
- English
- Date published
- 05/2019
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359787202771
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