Higher augmentation index is associated with tension-type headache and migraine in middle-aged/older humans with obesity

Graziela Z Kalil; Ana Recober; Ann Hoang-Tienor; Miriam Bridget Zimmerman; William G Haynes; Gary L Pierce

doi:10.1002/oby.21414

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Higher augmentation index is associated with tension-type headache and migraine in middle-aged/older humans with obesity

Journal article

Open access

Peer reviewed

Higher augmentation index is associated with tension-type headache and migraine in middle-aged/older humans with obesity

Graziela Z Kalil, Ana Recober, Ann Hoang-Tienor, Miriam Bridget Zimmerman, William G Haynes and Gary L Pierce

Obesity (Silver Spring, Md.), Vol.24(4), pp.865-870

04/2016

DOI: 10.1002/oby.21414

PMCID: PMC5539769

PMID: 26847595

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https://doi.org/10.1002/oby.21414View

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Abstract

Obesity is a major risk factor for chronic daily headaches, including migraine and tension-type headache (TTH). Although migraine is associated with increased risk of cardiovascular diseases (CVD), a relation between TTH and CVD risk has not been established. It was hypothesized that higher carotid-femoral pulse wave velocity (CFPWV) and augmentation index (AI), measures of aortic stiffness and pressure wave reflection, respectively, and biomarkers of CVD risk, would be higher among adults with obesity and migraine or TTH compared with those with no headache. Adults with obesity (n = 93; body mass index ≥30 kg/m(2) ) who were between 40 and 75 years old with at least one additional CVD risk factor were enrolled. Subjects had CFPWV and AI assessed and a complete neurological exam for diagnosis of headache in the past 12 months. Adults with obesity and TTH (P = 0.018), but not migraine (P = 0.29), had significantly higher AI compared with those with no headache. When both CFPWV and AI were considered in a logistic regression model with migraine or TTH, only AI was associated with TTH (P = 0.008) and migraine (P = 0.032) but could not distinguish between the two headache phenotypes. Increased aortic AI but not stiffness is associated with TTH and migraine among middle-aged/older adults with obesity and high CVD risk.

Cardiovascular Diseases - etiology

Cross-Sectional Studies

Pulse Wave Analysis

Obesity - complications

Humans

Middle Aged

Risk Factors

Biomarkers - analysis

Male

Obesity - physiopathology

Tension-Type Headache - physiopathology

Migraine Disorders - complications

Migraine Disorders - physiopathology

Adult

Female

Aged

Tension-Type Headache - complications

Vascular Stiffness

Details

Title: Subtitle: Higher augmentation index is associated with tension-type headache and migraine in middle-aged/older humans with obesity
Creators: Graziela Z Kalil - Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
Ana Recober - Department of Neurology, University of Iowa, Iowa City, Iowa, USA
Ann Hoang-Tienor - Department of Neurology, University of Iowa, Iowa City, Iowa, USA
Miriam Bridget Zimmerman - Institute for Clinical and Translational Science, University of Iowa, Iowa City, Iowa, USA
William G Haynes - Abboud Cardiovascular Research Center, University of Iowa, Iowa City, Iowa, USA
Gary L Pierce - Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, USA
Resource Type: Journal article
Publication Details: Obesity (Silver Spring, Md.), Vol.24(4), pp.865-870
Publisher: United States
DOI: 10.1002/oby.21414
PMID: 26847595
PMCID: PMC5539769
ISSN: 1930-7381
eISSN: 1930-739X
Grant note: HL014388 / NHLBI NIH HHS U54 TR001356 / NCATS NIH HHS T32 HL007121 / NHLBI NIH HHS AG043722 / NIA NIH HHS U54TR001356 / NCATS NIH HHS P01 HL014388 / NHLBI NIH HHS R21 AG043722 / NIA NIH HHS HL007121 / NHLBI NIH HHS
Language: English
Date published: 04/2016
Academic Unit: Biostatistics; Health and Human Physiology; Internal Medicine
Record Identifier: 9983997490402771

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