Higher plasma transforming growth factor (TGF)-β is associated with kidney disease in older community dwelling adults

Tapan Mehta; Petra Buzkova; Jorge R Kizer; Luc Djousse; Michel Chonchol; Kenneth J Mukamal; Michael Shlipak; Joachim H Ix; Diana Jalal

doi:10.1186/s12882-017-0509-6

Back

Higher plasma transforming growth factor (TGF)-β is associated with kidney disease in older community dwelling adults

Journal article

Open access

Peer reviewed

Higher plasma transforming growth factor (TGF)-β is associated with kidney disease in older community dwelling adults

Tapan Mehta, Petra Buzkova, Jorge R Kizer, Luc Djousse, Michel Chonchol, Kenneth J Mukamal, Michael Shlipak, Joachim H Ix and Diana Jalal

BMC nephrology, Vol.18(1), pp.98-98

03/21/2017

DOI: 10.1186/s12882-017-0509-6

PMCID: PMC5359982

PMID: 28327102

Files and links (1)

url

https://doi.org/10.1186/s12882-017-0509-6View

Published (Version of record) Open Access

Abstract

Background: TGF-β is induced in the vasculature with aging suggesting that high plasma TGF-β levels may be a risk factor for chronic kidney disease (CKD) in older adults. Methods: We conducted a cross-sectional analysis of the association between plasma TGF-β levels and CKD including data for 1722 older adults who had participated in the 1996/97 visit of the Cardiovascular Health Study (CHS). Prevalent CKD was defined as eGFR < 60 mL/min/1.73 m2 or urinary albumin/creatinine ratio (ACR) ≥30 mg/g. We also evaluated whether baseline TGF-β levels predicted change in eGFR, cardiovascular (CV) events, or mortality in longitudinal analysis. Results: Plasma TGF-β levels were significantly and independently associated with lower eGFR in cross-sectional analysis. Doubling of TGF-β was significantly associated with lower eGFR (β estimate after adjusting for CV risk factors = -1.18, 95% CI -2.03, -0.32). We observed no association with albuminuria. There was no association between baseline TGF-β and change in eGFR, but each doubling of TGF-β at baseline was associated with increased risk of a composite outcome of CV events and mortality, adjusted HR 1.10 (95% C.I. 1.02- 1.20, p = 0.006). Conclusion: In this large cohort of community-dwelling older individuals, high plasma TGF-β levels are modestly, but independently associated with lower eGFR but not with albuminuria in cross-sectional analysis. In addition, TGF-β levels are associated with increased risk of CV events and mortality. Further research is needed to determine the direction of association between plasma TGF-β and the risk of CKD and CKD-associated morbidities in older adults.

TGF-β

GFR

CKD

Older adults

Details

Title: Subtitle: Higher plasma transforming growth factor (TGF)-β is associated with kidney disease in older community dwelling adults
Creators: Tapan Mehta - Aurora, USA
Petra Buzkova - Seattle, USA
Jorge R Kizer - New York, USA
Luc Djousse - Boston, USA
Michel Chonchol - Aurora, USA
Kenneth J Mukamal - Boston, USA
Michael Shlipak - San Francisco, USA
Joachim H Ix - San Diego, USA
Diana Jalal - Aurora, USA
Resource Type: Journal article
Publication Details: BMC nephrology, Vol.18(1), pp.98-98
DOI: 10.1186/s12882-017-0509-6
PMID: 28327102
PMCID: PMC5359982
NLM abbreviation: BMC Nephrol
ISSN: 1471-2369
eISSN: 1471-2369
Publisher: BioMed Central
Grant note: AG023629 / ; N01HC85086; HL080295 / ; R01HL094555; R01DK098234 / ;
Language: English
Date published: 03/21/2017
Academic Unit: Nephrology; Internal Medicine
Record Identifier: 9984094485702771

Metrics

27 Record Views

26 Times Cited - Web of Science