Journal article
Hippocampal MR imaging morphometry by means of general pattern matching
Radiology, Vol.199(3), pp.787-792
1996
DOI: 10.1148/radiology.199.3.8638006
PMID: 8638006
Abstract
PURPOSE: To determine the repeatability and validity of a pattern-matching method for the segmentation and measurement of hippocampi on magnetic resonance (MR) images. MATERIALS AND METHODS: Comparable two-dimensional MR images obtained in 18 subjects (nine healthy control subjects [six men, three women; aged 24-54 years] and nine patients with schizophrenia [six men, three women; aged 22-61 years]) were twice segmented manually and twice segmented by using pattern matching with digital atlas transformation. The atlas transformation was accomplished in two steps: global followed by local matching. Global matching was performed with use of landmarks; local matching was performed with use of a viscous fluid model. RESULTS: The mean percentage of difference between two atlas-based measurements was 1.33% +/- 1.23 (+/- standard deviation); that between two manual measurements was 4.67% +/- 4.71. The validity of the atlas transformation measurements was demonstrated by means of the high correlation (intraclass correlation coefficient = .96) with manual segmentation measurements. Schizophrenic hippocampal areas tended to be smaller; however, no differences in hippocampal shape were found between patients with schizophrenia and patients with control subjects. CONCLUSION: General pattern matching of a digital brain atlas to an individual MR image is a mathematically robust method of measurement that is reproducible and less variable than manual measurement.
Details
- Title: Subtitle
- Hippocampal MR imaging morphometry by means of general pattern matching
- Creators
- J. W HALLER - Mallinckrodt Institute of Radiology, Washington University, 510 S Kingshighway Blvd, St Louis, MO 63110, United StatesG. E CHRISTENSEN - Mallinckrodt Institute of Radiology, Washington University, 510 S Kingshighway Blvd, St Louis, MO 63110, United StatesS. C JOSHI - Mallinckrodt Institute of Radiology, Washington University, 510 S Kingshighway Blvd, St Louis, MO 63110, United StatesJ. W NEWCOMER - Mallinckrodt Institute of Radiology, Washington University, 510 S Kingshighway Blvd, St Louis, MO 63110, United StatesM. I MILLER - Mallinckrodt Institute of Radiology, Washington University, 510 S Kingshighway Blvd, St Louis, MO 63110, United StatesJ. G CSERNANSKY - Mallinckrodt Institute of Radiology, Washington University, 510 S Kingshighway Blvd, St Louis, MO 63110, United StatesM. W VANNIER - Mallinckrodt Institute of Radiology, Washington University, 510 S Kingshighway Blvd, St Louis, MO 63110, United States
- Resource Type
- Journal article
- Publication Details
- Radiology, Vol.199(3), pp.787-792
- Publisher
- Radiological Society of North America; Oak Brook, IL
- DOI
- 10.1148/radiology.199.3.8638006
- PMID
- 8638006
- ISSN
- 0033-8419
- eISSN
- 1527-1315
- Language
- English
- Date published
- 1996
- Academic Unit
- Electrical and Computer Engineering; Radiation Oncology; Radiation Research Laboratory
- Record Identifier
- 9984047994402771
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