Journal article
Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults
eLife, Vol.9, e55335
05/29/2020
DOI: 10.7554/eLife.55335
PMCID: PMC7259949
PMID: 32469308
Abstract
Age-related episodic memory decline is characterized by striking heterogeneity across individuals. Hippocampal pattern completion is a fundamental process supporting episodic memory. Yet, the degree to which this mechanism is impaired with age, and contributes to variability in episodic memory, remains unclear. We combine univariate and multivariate analyses of fMRI data from a large cohort of cognitively normal older adults (N=100) to measure hippocampal activity and cortical reinstatement during retrieval of trial-unique associations. Trial-wise analyses revealed that (a) hippocampal activity scaled with reinstatement strength, (b) cortical reinstatement partially mediated the relationship between hippocampal activity and associative retrieval, (c) older age weakened cortical reinstatement and its relationship to memory behaviour. Moreover, individual differences in the strength of hippocampal activity and cortical reinstatement explained unique variance in performance across multiple assays of episodic memory. These results indicate that fMRI indices of hippocampal pattern completion explain within- and across-individual memory variability in older adults.
Details
- Title: Subtitle
- Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults
- Creators
- Alexandra N Trelle - Department of Psychology, Stanford University, Stanford, United StatesValerie A Carr - Department of Psychology, Stanford University, Stanford, United StatesScott A Guerin - Department of Psychology, Stanford University, Stanford, United StatesMonica K Thieu - Department of Psychology, Stanford University, Stanford, United StatesManasi Jayakumar - Department of Psychology, Stanford University, Stanford, United StatesWanjia Guo - Department of Psychology, Stanford University, Stanford, United StatesAyesha Nadiadwala - Department of Psychology, Stanford University, Stanford, United StatesNicole K Corso - Department of Psychology, Stanford University, Stanford, United StatesMadison P Hunt - Department of Psychology, Stanford University, Stanford, United StatesCelia P Litovsky - Department of Psychology, Stanford University, Stanford, United StatesNatalie J Tanner - Department of Psychology, Stanford University, Stanford, United StatesGayle K Deutsch - Department of Neurology & Neurological Sciences, Stanford University, Stanford, United StatesJeffrey D Bernstein - Department of Psychology, Stanford University, Stanford, United StatesMarc B Harrison - Department of Psychology, Stanford University, Stanford, United StatesAnna M Khazenzon - Department of Psychology, Stanford University, Stanford, United StatesJiefeng Jiang - Department of Psychology, Stanford University, Stanford, United StatesSharon J Sha - Department of Neurology & Neurological Sciences, Stanford University, Stanford, United StatesCarolyn A Fredericks - Department of Neurology & Neurological Sciences, Stanford University, Stanford, United StatesBrian K Rutt - Department of Radiology & Radiological Sciences, Stanford University, Stanford, United StatesElizabeth C Mormino - Department of Neurology & Neurological Sciences, Stanford University, Stanford, United StatesGeoffrey A Kerchner - Department of Neurology & Neurological Sciences, Stanford University, Stanford, United StatesAnthony D Wagner - Department of Psychology, Stanford University, Stanford, United States
- Resource Type
- Journal article
- Publication Details
- eLife, Vol.9, e55335
- DOI
- 10.7554/eLife.55335
- PMID
- 32469308
- PMCID
- PMC7259949
- NLM abbreviation
- Elife
- ISSN
- 2050-084X
- eISSN
- 2050-084X
- Publisher
- England
- Grant note
- R21 AG058859 / NIA NIH HHS R01 AG048076 / NIA NIH HHS R21 AG058111 / NIA NIH HHS
- Language
- English
- Date published
- 05/29/2020
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065826902771
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