Hippocampal subfield volumes in short- and long-term lithium-treated patients with bipolar I disorder

Alessio Simonetti; Gabriele Sani; Claudia Dacquino; Fabrizio Piras; Pietro De Rossi; Carlo Caltagirone; William Coryell; Gianfranco Spalletta

doi:10.1111/bdi.12394

Journal article

Hippocampal subfield volumes in short- and long-term lithium-treated patients with bipolar I disorder

Alessio Simonetti, Gabriele Sani, Claudia Dacquino, Fabrizio Piras, Pietro De Rossi, Carlo Caltagirone, William Coryell and Gianfranco Spalletta

Bipolar disorders, Vol.18(4), pp.352-362

06/2016

DOI: 10.1111/bdi.12394

PMID: 27237705

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Abstract

Patients diagnosed with bipolar disorder (BP) may experience hippocampal atrophy. Lithium exposure has been associated with increased hippocampal volumes. However, its effects on hippocampal subfields remain to be clarified. We investigated the effects of short- and long-term lithium exposure on the hippocampus and its subfields in patients affected by bipolar I disorder (BP-I). Hippocampal subfields and total hippocampal volumes were measured in 60 subjects divided into four groups: 15 patients with BP-I who were never exposed to lithium [no-exposure group (NE)], 15 patients with BP-I exposed to lithium for < 24 months [short-exposure group (SE)], 15 patients with BP-I exposed to lithium for > 24 months [long-exposure group (LE)], and 15 healthy control subjects (HC). The SE and NE groups showed smaller total hippocampal volumes and smaller bilateral cornu ammonis CA2-3, CA4-dentate gyrus (DG), presubiculum, and subiculum volumes compared with HC. The LE group showed larger total hippocampal volumes and bilateral CA2-3, left CA4-DG, left presubiculum, and right subiculum volumes compared with the NE group, and larger volumes of the right CA2-3, left CA4-DG, left presubiculum, and right subiculum compared with the SE group. No differences were found between the LE group and HC or between the SE and NE groups. Long-term, but not short-term, exposure to lithium treatment may exert neuroprotective effects on specific hippocampal subfields linked to disease progression.

Neuroimaging - methods

Diagnostic and Statistical Manual of Mental Disorders

Humans

Middle Aged

Lithium - pharmacokinetics

Magnetic Resonance Imaging - methods

Male

Hippocampus - pathology

Time

Hippocampus - drug effects

Bipolar Disorder - diagnosis

Bipolar Disorder - drug therapy

Disease Progression

Hippocampus - diagnostic imaging

Atrophy

Organ Size - drug effects

Neuroprotective Agents - pharmacokinetics

Adult

Female

Lithium - administration & dosage

Psychological Tests

Neuroprotective Agents - administration & dosage

Details

Title: Subtitle: Hippocampal subfield volumes in short- and long-term lithium-treated patients with bipolar I disorder
Creators: Alessio Simonetti - Centro Lucio Bini, Italy, IA
Gabriele Sani - Centro Lucio Bini, Italy, IA
Claudia Dacquino - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, Italy, IA
Fabrizio Piras - Centro Studi e Ricerche Enrico Fermi, Compendio del Viminale, Italy, IA
Pietro De Rossi - Centro Lucio Bini, Italy, IA
Carlo Caltagirone - Department of Medicine of Systems, Tor Vergata University of Rome, Italy, IA
William Coryell - Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA, USA
Gianfranco Spalletta - Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
Resource Type: Journal article
Publication Details: Bipolar disorders, Vol.18(4), pp.352-362
Publisher: Denmark
DOI: 10.1111/bdi.12394
PMID: 27237705
ISSN: 1398-5647
eISSN: 1399-5618
Language: English
Date published: 06/2016
Academic Unit: Psychiatry
Record Identifier: 9984003444902771

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