Journal article
Hippocampal sulcal cavities: Prevalence, risk factors and relationship to memory impairment
Brain research, Vol.1368(12), pp.222-230
01/12/2011
DOI: 10.1016/j.brainres.2010.10.089
PMID: 21040716
Abstract
While hippocampal volumes have been extensively examined in neuropsychiatric disorders and ageing, small areas of signal variation within the hippocampus commonly observed on MRI, described as hippocampal sulcal cavities (HSCs), have received less attention. We review the published literature on HSCs to examine their prevalence, putative aetiological factors such as hypertension, and possible cognitive correlates. HSCs were reported in 77% (66% weighted mean) of patients with memory disorders and 48% (47% weighted mean) of controls, and the prevalence increased with age in healthy subjects (r = 0.64, p = 0.047). A number of studies reported hypertension as a risk factor, and related their presence to poorer memory function. Further work is needed to fully understand the clinical significance of these lesions. (C) 2010 Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Hippocampal sulcal cavities: Prevalence, risk factors and relationship to memory impairment
- Creators
- Jerome J. Maller - Monash UniversityChantal Reglade-Meslin - Australian National UniversityPatrick Chan - The Alfred HospitalZafiris J. Daskalakis - Centre for Addiction and Mental HealthRichard H. S. Thomson - Monash UniversityKaarin J. Anstey - Australian National UniversityMarc Budge - Act HealthPerminder Sachdev - Prince of Wales HospitalPaul B. Fitzgerald - Monash University
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.1368(12), pp.222-230
- DOI
- 10.1016/j.brainres.2010.10.089
- PMID
- 21040716
- NLM abbreviation
- Brain Res
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Publisher
- Elsevier
- Number of pages
- 9
- Language
- English
- Date published
- 01/12/2011
- Academic Unit
- Radiology
- Record Identifier
- 9984848505502771
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