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Hippocampal sulcal cavities in depression and healthy individuals
Journal article   Peer reviewed

Hippocampal sulcal cavities in depression and healthy individuals

Jerome J. Maller, Chantal Reglade-Meslin, Richard H. S. Thomson, Melissa Daigle, Mera S. Barr, Zafiris J. Daskalakis and Paul B. Fitzgerald
Journal of affective disorders, Vol.150(3), pp.785-789
09/25/2013
DOI: 10.1016/j.jad.2013.02.039
PMID: 23541185
url
http://hdl.handle.net/1885/11521View
Open Access

Abstract

Background: A literature review suggested age and cognitive problems to be related to an increased prevalence of small areas of signal variation within the hippocampus observed on MRI, described as hippocampal sulcal cavities (HSCs; (Maller et al 2011)). The current study aimed to describe the prevalence of HSCs in patients with treatment resistant depression (TRD) and healthy controls over a large age range Methods: 115 TRD patients and 86 controls underwent MRI brain scanning. Right and left HSCs were rated separately for prevalence and length. Results: HSCs were observed in 73.04% of those with TRD, statistically more prevalent (p=0.001) than amongst controls (51.16%). These findings are consistent with our review (66% prevalence in memory disorders and 47% in healthy controls). Furthermore. HSC presence and length was associated with aging. Limitations: The study was cross-sectional so its implications for aging are tentative. A larger sample scanned longitudinally will allow for more sophisticated statistical methods by which to investigate the relationship between HSCs, aging, and TRD. Conclusions: Although their clinical significance remains uncertain, the results of the current study suggest that HSCs are related with age and those with TRD have more aged brains than their peers. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.
 Clinical Neurology Life Sciences & Biomedicine Neurosciences & Neurology Psychiatry Science & Technology

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