Hippocampal theta in the newborn rat is revealed under conditions that promote REM sleep

Karl Ae Karlsson; Mark S Blumberg

doi:10.1523/JNEUROSCI.23-04-01114.2003

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Hippocampal theta in the newborn rat is revealed under conditions that promote REM sleep

Journal article

Open access

Peer reviewed

Hippocampal theta in the newborn rat is revealed under conditions that promote REM sleep

Karl Ae Karlsson and Mark S Blumberg

The Journal of neuroscience, Vol.23(4), pp.1114-1118

02/15/2003

DOI: 10.1523/JNEUROSCI.23-04-01114.2003

PMCID: PMC6742265

PMID: 12598598

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Abstract

Hippocampal theta activity, a high-amplitude, slow (4-12 Hz) oscillation that occurs in a variety of behavioral contexts, is thought to emerge in infant rats only after 1 week of age. However, we report here that unanesthetized 2- and 4-d-old rats with electrodes implanted in the CA1 field of the hippocampus and tested in thermoneutral conditions exhibit theta activity. Moreover, this infant theta is characterized by the same neuronal bursting pattern and power spectrum that characterize theta in adults. Simultaneous measures of behavior and neck muscle tone indicated that bouts of theta occurred predominantly during periods of muscle atonia (with or without concurrent myoclonic twitching), indicative of REM sleep. In contrast, sharp waves were accompanied by startles (i.e., simultaneous and vigorous movement of all four limbs). These findings underscore the need for comprehensive in vivo investigations of the pharmacology, neural substrates, and behavioral correlates of hippocampal field activity in neonates.

Animals, Newborn

Temperature

Rats

Male

Rats, Sprague-Dawley

Action Potentials

Behavior, Animal

Animals

Reflex, Startle

Female

Electromyography

Muscle Hypotonia

Sleep, REM

Hippocampus - physiology

Hippocampus - growth & development

Theta Rhythm

Details

Title: Subtitle: Hippocampal theta in the newborn rat is revealed under conditions that promote REM sleep
Creators: Karl Ae Karlsson - Program in Behavioral and Cognitive Neuroscience, Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
Mark S Blumberg
Resource Type: Journal article
Publication Details: The Journal of neuroscience, Vol.23(4), pp.1114-1118
DOI: 10.1523/JNEUROSCI.23-04-01114.2003
PMID: 12598598
PMCID: PMC6742265
NLM abbreviation: J Neurosci
ISSN: 0270-6474
eISSN: 1529-2401
Publisher: United States
Grant note: MH50701 / NIMH NIH HHS MH66424 / NIMH NIH HHS HD38708 / NICHD NIH HHS
Language: English
Date published: 02/15/2003
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Biology
Record Identifier: 9984002429902771

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