Journal article
Hippocampal volume in first episode and recurrent depression
Psychiatry research, Vol.174(1), pp.62-66
10/30/2009
DOI: 10.1016/j.pscychresns.2008.08.001
PMID: 19800203
Abstract
Abnormalities in limbic-thalamic-cortical networks are hypothesized to modulate human mood states. In the present study differences in hippocampal volumes of patients with a first episode of depression, recurrent major depression and healthy control subjects were examined with high-resolution magnetic resonance imaging (MRI). Male patients with a first episode of major depression had a significantly smaller left hippocampal volume than male control subjects. Also, these patients had a significant left-right asymmetry in hippocampal volume. Female patients showed no significant alterations in hippocampal volumes. The results support the hypothesis that the hippocampus plays an important role in the pathophysiology of the early phase of major depression, especially for male patients. Implications for the neurodevelopmental and the neurodegenerative model of hippocampal change are discussed.
Details
- Title: Subtitle
- Hippocampal volume in first episode and recurrent depression
- Creators
- Klaus-Thomas Kronmüller - Department of Psychiatry, University of Heidelberg, Germany. klaus_kronmueller@med.uni-heidelberg.deJohannes SchröderSebastian KöhlerBianca GötzDaniela VictorJörg UngerFrederic GieselVincent MagnottaChristoph MundtMarco EssigJohannes Pantel
- Resource Type
- Journal article
- Publication Details
- Psychiatry research, Vol.174(1), pp.62-66
- Publisher
- Ireland
- DOI
- 10.1016/j.pscychresns.2008.08.001
- PMID
- 19800203
- ISSN
- 0165-1781
- eISSN
- 1872-7123
- Language
- English
- Date published
- 10/30/2009
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984051513702771
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