Journal article
Hippocampal volumetrics in depression: the importance of the posterior tail
Hippocampus, Vol.17(11), pp.1023-1027
01/01/2007
DOI: 10.1002/hipo.20339
PMID: 17604352
Abstract
Studies of patients with major depression disorder (MDD) have revealed reduced hippocampal volumes, but findings have been inconsistent due to sample and measurement differences. The current study sought to measure this structure in a large sample of MDD and control subjects, using a strict measurement protocol, in order to elucidate morphological-specific volumetric differences. Forty-five subjects with treatment-resistant MDD and 26 controls underwent psychiatric assessments and brain magnetic resonance imaging (MRI). The findings of this study indicate that (1) MDD results in reduced hippocampal volume, particularly in the tail section, (2) region of interest (ROI) estimation protocols and sample characteristics may help explain volumetric differences between previous MDD studies, and (3) specific ROI atrophy in treatment-resistant depression is influenced by sex.
Details
- Title: Subtitle
- Hippocampal volumetrics in depression: the importance of the posterior tail
- Creators
- Jerome J Maller - Monash Alfred Psychiatry Research centreZ Jeff Daskalakis - Centre for Addiction and Mental HealthPaul B Fitzgerald - Monash Alfred Psychiatry Research centre
- Resource Type
- Journal article
- Publication Details
- Hippocampus, Vol.17(11), pp.1023-1027
- DOI
- 10.1002/hipo.20339
- PMID
- 17604352
- NLM abbreviation
- Hippocampus
- ISSN
- 1050-9631
- eISSN
- 1098-1063
- Language
- English
- Date published
- 01/01/2007
- Academic Unit
- Radiology
- Record Identifier
- 9984848508802771
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